To date, human African trypanosomiasis (HAT) still threatens millions of people throughout sub-Sahara Africa, and new approaches to disease prevention and treatment remain a priority. It is commonly accepted that HAT is fatal unless treatment is provided. However, despite the well-described general symptoms of disease progression during distinct stages of the infection, leading to encephalitic ...

We define a small step operational semantics for a core of Haskell. We modify this semantics to generate traces, specifically Augmented Redex Trails. This small and direct definition of Augmented Redex Trails shall improve our understanding of them and shall help to extend them systematically. 1 Hat — The Haskell Tracer Hat is a tool for viewing the computation of a Haskell program in various w...

BACKGROUND Diagnosis of human African trypanosomiasis (HAT) remains a challenge both for active screening, which is critical in control of the disease, and in the point-of-care scenario where early and accurate diagnosis is essential. Recently, the first field deployment of a lateral flow rapid diagnostic test (RDT) for HAT, "SD BIOLINE HAT" has taken place. In this study, we evaluated the perf...

In this paper we introduce new modified implicit and explicit algorithms and prove strong convergence of the two algorithms to a common fixed point of a family of uniformly asymptotically regular asymptotically nonexpansive mappings in a real reflexive Banach space  with a uniformly G$hat{a}$teaux differentiable norm. Our result is applicable in $L_{p}(ell_{p})$ spaces, $1 < p

Nach dem kurzen Bericht ueber die Geschichte van Tetanus; haben wir in diesern Artikel ver­sucht,ueber die Epedirniologie, Pathophisiolo­gie,Aethiologie und die Frueh-und Spaet-Symp­ptome von dieser gcfahrlichen Krankheit,die einen Durchschnitt von 35% Mortalitaet hat,zu berichten.  In disern Artikel legen wir vi.ei wert,besoaders ueber die The·.rapie 1md der Prophyla.xe. Unc:I wii' hal)en bed...

BACKGROUND Because of its high sensitivity and its ease of use in the field, the card agglutination test for trypanosomiasis (CATT) is widely used for mass screening of sleeping sickness. However, the CATT exhibits false-positive results (i) raising the question of whether CATT-positive subjects who are negative in parasitology are truly exposed to infection and (ii) making it difficult to eval...

Tip60 is a 60 kDa nuclear protein which exists in three isoforms, belongs to the MYST/HAT family of proteins and was discovered after its interaction with the Human HIV-1 Tat. As a nuclear protein, Tip60 can act as a coactivator or repressor. To understand the HAT action of Tip60, two possible catalytic models exist; the ping-pong and the ternary complex formation models. In correlation with th...

Histone acetyltransferases (HAT) play a critical role in transcriptional control by relieving repressive effects of chromatin, and yet how HATs themselves are regulated remains largely unknown. Here, it is shown that Twist directly binds two independent HAT domains of acetyltransferases, p300 and p300/CBP-associated factor (PCAF), and directly regulates their HAT activities. The N terminus of T...

BACKGROUND Human African trypanosomiasis (HAT), or sleeping sickness, is a fatal neglected tropical disease if left untreated. HAT primarily affects people living in rural sub-Saharan Africa, often in regions afflicted by violent conflict. Screening and treatment of HAT is complex and resource-intensive, and especially difficult in insecure, resource-constrained settings. The country with the h...