SFI WORKING PAPER: 2014-04-006 SFI Working Papers contain accounts of scientific work of the author(s) and do not necessarily represent the views of the Santa Fe Institute. We accept papers intended for publication in peer-reviewed journals or proceedings volumes, but not papers that have already appeared in print. Except for papers by our external faculty, papers must be based on work done at ...

cancer is one of the causes of death in the world. several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...

Enteropathogenic E. coli (EPEC) is a human pathogen using type III secretion system for delivery of proteins directly into the human host. The system contains a single ATPase, EscN, which is essential for uncoupling of proteins from their complexes with chaperones before the delivery. The structure of EscN ATPase (PDB code: 2obm) was used to construct a search template to screen computationally...

similarities to glandular carcinoma. On the other hand, dysregulation of the in silico principle governing proliferation had muted effects on growth morphologies. Comparatively, the 2 alterations and their misbalance gave rise to distinct morphologies that mark intermediate stages of a simulated progression toward malignancy. In cases where unchecked growth was observed, we identified structura...

introduction: influenza a virus causes unpredictable epidemics and pandemics by creating antigenic variations. with the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. hence, designing an applicable and cross protective strategy to counter this virus is of great importance. to achieve this, choosing conserved antigenic regions in influenza virus...

ابتلای یکی از اعضای خانواده به بیماری مزمن، بر روابط، نقش‌ها، سلسله مراتب و به‌طور کلی سیستم تأثیر می‌گذارد را برای مدیریت سازگاری با شرایط جدید، چالش‌هایی مواجه می‌کند. هدف این مرور ادبیات پژوهشی، شناسایی مسائلی است که در مزمن اعضا، آن رو‌به‌روست. بدین منظور، بررسی نظام‌مند مقالات چاپ‌شده زبان فارسی یا انگلیسی مجلات داخلی خارجی سال 201۴ (دی ۱۳۹۲) تاکنون، پایگاه‌های SID، Magiran، Google Scholar...

It is now widely accepted that animal behavior optimizes certain performance criteria. The question is, which criteria are being optimized? To answer this question, today, ethologists start by conducting some exploratory experiments. After the preliminary data is gathered, they infer a set of potential hypotheses. In order to find out which hypothesis is more likely to be correct, they have to ...

Bacteria are able to sense their environment and move towards sources of attractant and away from sources of repellent through the process of chemotaxis. The best understood model for chemotaxis comes from Escherichia coli, where the biochemical pathways have been extensively studied. In E. coli, the bacterium switches between swimming and tumbling based on the changes in the local concentratio...

An in silico tool that can be utilized in the clinic to predict neoplastic progression and propose individualized treatment strategies is the holy grail of computational tumor modeling. Building such a tool requires the development and successful integration of a number of biophysical and mathematical models. In this paper, we work toward this long-term goal by formulating a cellular automaton ...