* لوئسم هدنسيون : فيرـش نابايخ ،ناهفصا يوـك ،يـفقاو نب ،يناطلس نسحم ديهش حرف تسب كلاپ ،شخب 10 / 8 نفلت : 3168058 0913 email: [email protected] فده و هنيمز : ميزنآ نيرتمهم زا زانژيسكا ولكيس ميزنآ نيدنلاگاتسورپ زتنس ريسم ياه ا شياديپ و اه ندب رد باهتل تسا ناسنا . هزات رد رثا تاقيقحت نيرت ت رخ ي زانژيسكا ولكيس ميزنا زا يب 2 لولس رب هدش هديد ناسنا زغم يبصع ياه ب تسا ه يروط...

Background: Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor (TGF)-β receptors and platelet-derived growth factor (PDGF) receptors. However, its effect on peritoneal fibrosis is unknown. Here, we investi...

BACKGROUND TKI-acquired resistance is a tough obstacle for effectively treating NSCLC patients with EGFR mutant characteristics. T790M mutations and MET amplifications account for 70% of the acquired resistance, but the causes for the remaining 30% need elucidation. METHODS We detected TGF-β1and PTEN expression levels in 51 NSCLC patients undergoing EGFR-TKI treatment using Immunohistochemist...

To investigate the role of iron and active oxygen species (AOS) in asbestos-induced fibrosis, we loaded increasing amounts of Fe(II)/Fe(III) onto the surface of amosite asbestos fibers and then applied the fibers to rat tracheal explants. Explants were harvested after 7 d in air organ culture. Asbestos by itself doubled procollagen gene expression, and a further increase was seen with increasin...

The epithelial-mesenchymal transition (EMT) and its reversal, mesenchymal-epithelial transition (MET), are fundamental processes involved in tumor cell invasion and metastasis. SEMA3F is a secreted semaphorin and tumor suppressor downregulated by TGF-β1 and ZEB1-induced EMT. Here, we report that neuropilin (NRP)-2, the high-affinity receptor for SEMA3F and a coreceptor for certain growth factor...

The transforming growth factor-beta (TGF-beta) family of cytokines regulates cell proliferation, morphogenesis, and specialized cell functions in metazoans. Herein, we screened a compound library for modifiers of TGF-beta signaling in NMuMG epithelial cells using a cell-based assay to measure Smad2/3 nuclear translocation. We identified five enhancers of TGF-beta signaling that share a core str...

BACKGROUND The notion that diabetic nephropathy is the leading cause of renal fibrosis prompted us to investigate the effects of blood glucose fluctuation (BGF) under high glucose condition on kidney in the mice. METHODS The diabetic and BGF animal models were established in this study. Immunohistochemistry, Western blot, and RT-PCR analysis were applied to detect the expression of type I col...

مداخل يعسوت رامعم ميمصت " ةجاحلا بسح ةددعتم طئاسو " ABSTRACT in this paper we develop a Vhdlbased scalable architecture of a multimedia on demand server model. Te three server subsystems are:the control subsystem, the communication subsystem and the storage subsystem are modeled. The communication subsystem is designed as an interconnection network with meshed-pipe structure and delivers packe...

TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8 (IL-8), a neutrophil chemoattractant and an angiogenic factor with tumor promoting properties. As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs, we hypothesized that ...

1 يوجشناد سانشراک ی ،هیذغت مولع دشرا ،نارهت یکشزپ مولع هاگشناد ،یسانش میژر و هیذغت هدکشناد ناریا 2 لوئسم هدنسیون : هورگ رایداتسا هیذغت هعماج ،ناریا ،نارهت یکشزپ مولع هاگشناد ،یسانش میژر و هیذغت هدکشناد ، یکینورتکلا تسپ : [email protected] 3 داتسا هورگ هیذغت هعماج هدکشناد، هیذغت میژرو هاگشناد،ینامرد مولع یکشزپ ،نارهت ناریا 4 يارتکد تملاس تاقیقحت یلم وتیتسنا ،ناهفصا یتشادهب ت...