Salmonella enterica serovar typhimurium a hyperreplicating population, exists inside the cytoplasm of infected epithelial cells. This population expresses genes belonging to the Salmonella Pathogenicity Island 1 (SPI-1) after exiting from the Salmonella Containing Vacuole (SCV) (Knodler, et al., 2010) (Beuzon, et al., 2002). SCV provides a protective niche to Salmonella typhimurium and the reas...

background :    salmonellosis is an infectious and a food-borne disease of humans and animals. the initial source of the infection is the intestinal tracts of birds and other animals. apparently healthy animals can become subclinical carriers and persistently shed salmonella in their feces which can act as a reservoir for the pathogen. the aim of this study is to detect the carriers of salmonel...

The pathogenicity of Salmonella Kentucky, Salmonella Typhimurium, Salmonella Shubra and Salmonella Enteritidis were investigated in specific-pathogenfree chicks (SPF) and BALB/c mice. Mortality rates after the 1 st week of infection with the four serovars, only S. Typhimurium and S. Enteritidis produced a fulminate infection (88%) in each of the chicks and mice. The lowest mortality was seen in...

Distinct peptide-MHC-II complexes, recognised by Type A and B CD4(+) T-cell subsets, are generated when antigen is loaded in different intracellular compartments. Conventional Type A T cells recognize their peptide epitope regardless of the route of processing, whereas unconventional Type B T cells only recognise exogenously supplied peptide. Type B T cells are implicated in autoimmune conditio...

The effectiveness of radiation treatment in eliminating Salmonella Typhimurium and Listeria monocytogenes on laboratory inoculated ready-to-eat sprouts was studied. Decimal reduction doses (D10-values) for Salmonella Typhimurium and L. monocytogenes in dry seeds of mung (green gram), matki (dew gram), chana (chick pea), and vatana (garden pea) ranged from 0.189 to 0.303 kGy and 0.294 to 0.344 k...

In order to be able to come up with efficient control measures to combat Salmonella infections in pigs, for example by means of vaccination, detailed knowledge of the pathogenesis should be the starting point. Transmission of Salmonella between pigs is thought to occur mainly via the faecal–oral route. Depending on the inoculation dose and the used strain, experimental oral infection of pigs wi...

Multilocus sequence typing (MLST) is a relatively new high-resolution typing system employed for epidemiological studies of bacteria, including Salmonella. Discrimination based on MLST of housekeeping genes may be problematical, due to the high identity of gene sequences of closely related Salmonella species. The presence of genomic sequences derived from stable temperate phages in Salmonella o...

The effects of three temperatures (5, 15, and 25 degrees C) on the survival of Salmonella enterica serovar Typhimurium in topsoil were investigated in small microcosms by three different techniques: plate counting, invA gene quantification, and invA mRNA quantification. Differences in survival were related to the effect of protozoan predation. Tetracycline-resistant Salmonella serovar Typhimuri...

Salmonellae are pathogenic bacteria that induce immunosuppression by mechanisms that remain largely unknown. Previously, we showed that a putative type II l-asparaginase produced by Salmonella Typhimurium inhibits T cell responses and mediates virulence in a murine model of infection. Here, we report that this putative L-asparaginase exhibits L-asparagine hydrolase activity required for Salmone...