Many viruses which cause disease including human immunodeficiency virus HIV and influenza are “enveloped” by a membrane and infection of a host cell begins with joining or “fusion” of the viral and target cell membranes. Fusion is catalyzed by viral proteins in the viral membrane. For HIV and for the influenza virus, these fusion proteins contain an 20-residue apolar “fusion peptide” that binds...

BACKGROUND Highly aggressive tumors are exposed to hypoxia and increased tumor interstitial fluid pressure (IFP) conditions which is resistant to blood supply. Physiological responses of the organism may reduce IFP through induction of orderly cell death. SPECIFIC AIMS This study demonstrates that orderly cell death provided spatial structure for early angiogenesis in the hypoxic, high-IFP tu...

MSCs from non-cartilaginous knee joint tissues such as the infrapatellar fat pad (IFP) and synovium possess significant chondrogenic potential and provide a readily available and clinically feasible source of chondroprogenitor cells. Fibroblast growth factor-2 (FGF-2) has been shown to be a potent mitotic stimulator during ex vivo expansion of MSCs, as well as regulating their subsequent differ...

Abstract The current GFDL seasonal prediction system, the Seamless System for Prediction and Earth Research (SPEAR), has shown skillful of Arctic sea ice extent with atmosphere ocean constrained by observations. In this study we present improvements in subseasonal predictions directly assimilating initial conditions from a data assimilation (DA) system that assimilates satellite concentration (...

Towards Integrated Powertrain Control for a Mild-Hybrid Urban Vehicle with a Downsized Turbo-Charged CNG Engine — Compressed natural gas (CNG) is considered as one of the most promising alternative fuels for transportation due to its ability to reduce greenhouse gas emissions (CO2, in particular) and its abundance. An earlier study from IFP has shown that CNG has a considerable potential when u...

OBJECTIVE To assess current infant feeding practices (IFP) in a relocated slum, to identity the lacunae, to outline, implement, and evaluate the gain in awareness and IFP followed by mothers. METHODS Thirty-five mothers of infants aged 5-19 months were interviewed. Based on lacunae, Nutrition Education (NE) was imparted to mothers over two months. Tools used were individual counseling, partic...

A graph G = ( b’. El has bandwidth k under a layout L : V 4’ ’ { 1. . . . , 1 VJ} if, for all {s. y} E E. jL(x 1 -L(y)] s k. Bandwidth constraints on several problems that are complete for [Fp (under log space reductions) are considered. In particular, the solvable path system problem and the and/or graph accessibility problem under various bandwidth constraints are used to prove results about ...

The evaluation of angiogenesis inhibitors requires the analysis precise structure and function tumor vessels. anti-angiogenic agents lenvatinib sorafenib are multi-target tyrosine kinase that have been approved for treatment hepatocellular carcinoma (HCC). However, different effects on vasculature between not well understood. In this study, we analyzed both drugs vascular function, including no...