BACKGROUND Lipotoxicity may be a key contributor to the pathogenesis of cardiac abnormalities in mitochondrial long-chain fatty acid β-oxidation (FAO) disorders. Few data are available on myocardial lipid levels and cardiac performance in FAO deficiencies. The purpose of this animal study is to assess fasting-induced changes in cardiac morphology, function, and triglyceride (TG) storage as a co...

Expression of the galectin-1 (L-14-I) gene, elevated in most differentiated and transformed cell lines, has been studied in cell hybrid systems. Fusion of L-14-I nonproducing rat liver differentiated FAO cells with dedifferentiated rat liver BRL3A cells leads to extinction of liver-specific gene expression while L-14-I mRNA levels remain high. Interspecific hybrids produced by fusion of tumorig...

Studies have shown that decreased mitochondrial content and function are associated with hepatic steatosis. We examined whether peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocytes (in vitro) and Sprague-Dawley rats (in vivo) would comprehensively alter mitochondrial lipid m...

In 2010, the Food and Agriculture Organization of the United Nations (FAO) estimated that 16 million hectares of forest per year were lost globally in the 1990s ( FAO 2010 ), and approximately 12.5 million hectares/year were lost in countries with primate populations, an area just smaller than Greece or the US State of Mississippi (Chapman and Peres 2001 ; Chapman and Gogarten 2012 ). In contra...

RATIONALE Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rodents with reduced PGC-1α expression. OBJECTIVE To determine the role of PGC-1β in maintaining mitochondrial energy metabolism and contractile function in pressure overload hype...

The main goal of this study is to evaluate the potential of the FAO-56 dual technique for the estimation of regional evapotranspiration (ET) and its constituent components (crop transpiration and soil evaporation), for two classes of vegetation (olives trees and cereals) in the semi-arid region of the Kairouan plain in central Tunisia. The proposed approach combines the FAO-56 technique with re...

Schistosomes, parasitic flatworms that cause the neglected tropical disease schistosomiasis, have been considered to have an entirely carbohydrate based metabolism, with glycolysis playing a dominant role in the adult parasites. However, we have discovered a close link between mitochondrial oxygen consumption by female schistosomes and their ability to produce eggs. We show that oxygen consumpt...

The role of Sun2 has been described by previous studies in various types of cancers, including breast cancer and lung cancer. However, its role and potential molecular mechanism in the progression of prostate cancer have not been fully elucidated. In the present study, we found that Sun2 expression was reduced in prostate cancer tissues compared with paired normal tissues, and that low expressi...

s of each presentation were prepared by the authors themselves. They solely reflect their point of view. The sections “discussion/issues raised”, which follow each abstract, have been drafted by the secretariat according to key issues raised and book marked as such during the final discussion, further edited by the author of the papers and submitted for final review to all participants. Activit...