Figure S1. Caspase-11-/-mice show increased morbidity to colitis induced with 4% DSS (a) The percentage of body weight and (b) the clinical score of C57BL/6J, C11-/-and C1-/-/11-/-mice induced with 4% DSS (n = 10 per group). Data depict the mean ± SEM. Statistical significance between DSS-treated C57BL/6J and C11-/-mice is indicated.

Decision support is a crucial function for decision makers in many industries. Typically, decision support systems help decision-makers to gather and interpret information and build a foundation for decision-making. Medical Decision Support Systems (DSS) play an increasingly important role in medical practice. By assisting physicians with making clinical decisions, DSS are expected to improve t...

This paper presents an integrated method to help design and implement a Web-based Decision Support Systems (DSS) in a distributed environment. First, a layered software architecture is presented to assist in the design of a Web-based DSS. The layered software architecture can provide a formal and hierarchical view of the Web-based DSS at the design stage. Next, a component-based framework is pr...

As the web platform continues to mature, we see an increasing number of amazing technologies that take DSS (Decision Support Systems) to new levels of power and usability. By integrating new powerful technologies into DSS, we get higher performance results with additional functionalities. The most recent development capturing the attention of the browser based application developers are Web Ser...

This study investigates the contributions of artificial intelligence to the development of decision support systems research subspecialties. Author cocitation analysis was applied to an author cocitation frequency matrix derived from a comprehensive database of the DSS literature (1970-1995) to uncover twelve clusters consisting of six major areas of DSS research (foundations, group DSS, model ...

Purpose –The knowledge of artefact design in design science research can have an important application in the improvement of decision support systems (DSS) development research. Recent DSS literature has identified a significant need to develop user-centric DSS method for greater relevance with respect to context of use. To address this, this study develops a collective DSS design artefact as m...

BACKGROUND Patients with developmental spinal stenosis (DSS) are susceptible to developing symptomatic stenosis due to pre-existing narrowed spinal canals. DSS has been previously defined by MRI via the axial anteroposterior (AP) bony spinal canal diameter. However, MRI is hardly a cost-efficient tool for screening patients. X-rays are superior due to its availability and cost, but currently, t...

BACKGROUND Hyperhomocysteinaemia [HHcy] is a common phenomenon observed in patients with inflammatory bowel disease [IBD]. Homocysteine is a pro-inflammatory molecule and has been identified as a risk factor for cardiovascular and cerebral diseases. Whether HHcy contributes to the chronic inflammation of the colon in IBD has rarely been explored. The aim of this study was to investigate the eff...

The effects of modulating tetrahydrobiopterin (BH4) levels with a metabolic precursor, sepiapterin (SP), on dextran sodium sulfate (DSS)–induced colitis and azoxymethane (AOM)–induced colorectal cancer were studied. SP in the drinking water blocks DSS-induced colitis measured as decreased disease activity index (DAI), morphologic criteria, and recovery of Ca-induced contractility responses lost...

Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC), results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies are needed. One candidate is the semi-essential amino acid, L-arginine (L-Arg), a complementary medicine purported to be an enhancer of immunity and vitality in the lay media. Using dextran sulfate sodium (D...