Download creatic cancer (PC) is a highly lethal disease with complex etiology involving both environmental netic factors. Although cigarette smoking is known to explain 25% of cases, data from recent studies sugat obesity and long-term type II diabetes are twomajor modifiable risk factors for PC. Furthermore, obed diabetes seem to affect the clinical outcome of patients with PC. Understanding t...

Sepsis is a common post-operative complication, which may account for one-third of all cases of sepsis.1 Patients who develop sepsis during or after surgery can progress to multiple organ dysfunction, and have a signifi cantly greater mortality rate during their hospital stay.2-4 The cost of treating such patients was estimated as three times higher than treating surgical patients without posto...

Vismodegib (GDC-0449), an orally bioavailable small-molecule inhibitor of Hedgehog signaling, was recently approved by the U.S. Food and Drug Administration for the treatment of basal cell carcinoma that is either metastatic or locally advanced in patients who are not candidates for surgical resection or radiation. Given the absence of previously defined effective drug therapy for this disease,...

BACKGROUND The aims of the present study were to examine relations between parents' self-reported smoking behavior and infants' daily exposure to environmental tobacco smoke, as assessed by urinary cotinine-to-creatinine ratio (CCR), and to describe the CCR over seven days among infants at home. METHODS A convenience sample of 27 households was drawn. Each household had to have at least one d...

We report two cases of gastric cancer with peritoneal carcinomatosis successfully responding to combination chemotherapy of S-1 and cisplatin, leading to a clinical complete response (cCR). In case 1, a 60-year-old woman achieved a cCR after 6 cycles of S-1 and cisplatin. Eight cycles of S-1 and cisplatin and 16 cycles of S-1 alone were administered. Since treatment with S-1 alone, only observa...

PURPOSE The purpose of this study was to determine whether chemoradiation (CCR) is efficient for improving prognosis, compared with systemic chemotherapy (SC), in patients with stage IVB cervical cancer who have distant lymphatic metastasis. MATERIALS AND METHODS Among 2,322 patients with cervical cancer between January 2000 and March 2010, 43 patients (1.9%) had stage IVB disease. After excl...

در این پژوهش سعی می‌­شود مدلی برای شبیه‌­سازی چرخه عمر صنعت برق با استفاده از شبیه‌سازی عامل­بنیان ارائه شود، مدل، 5 عامل استخراج شد و شبیه­‌سازی به کمک نرم‌افزار Anylogic صورت پذیرفت. بهینه‌­سازی مدل چهار سناریو نظر خبرگان شد. سناریوی نخست، جذابیت نیروگاه گازی سیکل ترکیبی کاهش یافت بر دو دیگر افزوده نتیجه افزایش تولید آبی است که توجه کمبود منابع کشور به‌صرفه نیست. دوم ورود یک فناوری جدید میزان...