The effects of polyethylene glycol (PEG) 200 administered by gavage on electrolyte and water excretion were investigated in the rat. PEG 200 led, in intact rats, to dose-related increased drinking and to diuresis. In the first 2 h after PEG 200 administration, water consumption in intact rats exceeded urine output. PEG 200 enhanced the excretion of both sodium and potassium, but the sodium excr...

The physicochemical properties of Doxorubicin–PEG–FOL and Daunorubicin-PEG-FOL ( Doxorubicin and Daunorubicin conjugated to polyethylene glycol–folate nanoparticles) have been estimated using Density functional Theory (DFT) and Hartree Fock(HF) calculations.In this report some geometrical parameters of Doxorubicin-PEG-FOL complex of the conjugated complex and Daunorubicin–PEG–FOL complex of the...

Percutaneous endoscopic gastrostomy (PEG) has become the modality of choice for providing enteral access to patients who require long-term enteral nutrition. Although generally considered safe, PEG tube placement can be associated with many potential complications. This review describes a variety of PEG tube related complications as well as strategies for complication avoidance. In addition, th...

The paper discusses general problems in using PEG for conjugation to high or low molecular weight molecules. Methods of binding PEG to different functional groups in macromolecules is reported together with their eventual limitations. Problems encountered in conjugation, such as the evaluation of the number of PEG chains bound, the localisation of the site of conjugation in polypeptides and the...


 Purpose: To evaluate the characteristics and biodistribution of trans resveratrol-PEG-folic acid-gold nanoparticle conjugates (rsv-PEG-FA-AuNP).
 Methods: Gold nanoparticles were produced by citric reduction followed conjugation PEG-folic acid resveratrol. Characterization rsv-PEG-FA-AuNP including their particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR), ...

Immunomodulatory drugs are of great relevance in the context vaccine delivery and cancer immunotherapy. Due to ubiquitous presence immune cells throughout body, gaining control over biodistribution activity such is crucial limit off-target inflammatory responses. Here, authors report on lipid-PEG (polyethylene glycol) amphiphiles as well-defined amphiphilic carries for lymph node targeted deliv...

BACKGROUND Conventional chemotherapy agent such as doxorubicin (DOX) is of limited clinical use because of its inherently low selectivity, which can lead to systemic toxicity in normal healthy tissue. METHODS A pH stimuli-sensitive conjugate based on polyethylene glycol (PEG) with covalently attachment doxorubicin via hydrazone bond (PEG-hyd-DOX) was prepared for tumor targeting delivery syst...