Polychlorinated biphenyls (PCBs) and the structurally related polybrominated diphenyl ethers (PBDEs) are abundant persistent organic pollutants that exert several comparable neurotoxic effects. Importantly, hydroxylated metabolites of PCBs and PBDEs have an increased neurotoxic potency. Recently, we demonstrated that PCBs can act as (partial) agonist on GABA(A) neurotransmitter receptors, with ...

MacLean, David A., Virginia A. Imadojemu, and Lawrence I. Sinoway. Interstitial pH, K1, lactate, and phosphate determined with MSNA during exercise in humans. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R563–R571, 2000.—The purpose of the present study was to use the microdialysis technique to simultaneously measure the interstitial concentrations of several putative stimulators ...

Zhang, Rong, Julie H. Zuckerman, and Benjamin D. Levine. Spontaneous fluctuations in cerebral blood flow: insights from extended-duration recordings in humans. Am J Physiol Heart Circ Physiol 278: H1848–H1855, 2000.—To determine the dependence of cerebral blood flow (CBF) on arterial pressure over prolonged time periods, we measured beat-to-beat changes in mean CBF velocity in the middle cerebr...

Mennitt, Patricia A., Gustavo Frindt, Randi B. Silver, and Lawrence G. Palmer. Potassium restriction downregulates ROMK expression in rat kidney. Am J Physiol Renal Physiol 278: F916–F924, 2000.—The ROMK family of proteins has biophysical properties and distribution within the kidney similar to those of secretory potassium channels of the distal nephron. To study the regulation of ROMK during v...

Juel, Carsten, Jens Jung Nielsen, and Jens Bangsbo. Exercise-induced translocation of Na1-K1 pump subunits to the plasma membrane in human skeletal muscle. Am J Physiol Regulatory Integrative Comp Physiol 278: R1107– R1110, 2000.—Six human subjects performed one-legged knee extensor exercise (90 6 4 W) until fatigue (exercise time 4.6 6 0.8 min). Needle biopsies were obtained from vastus latera...

XIAO-MEI LI,1 XU-HUI LIU,1 ELISABETH FILIPSKI,1 GÉRARD METZGER,1 PHILIPPE DELAGRANGE,2 JEAN-PHILIPPE JEANNIOT,3 AND FRANCIS LÉVI1 1Laboratoire ‘‘Rythmes Biologiques and Chronothérapeutique,’’ Institut du Cancer et d’Immunogénétique et Université Paris XI, Hôpital Paul Brousse, 94807 Villejuif Cedex; 2Institut de Recherches Internationales Servier, 92415 Courbevoie; and 3Technologie Servier, 450...

Welsh, Donald G., and Steven S. Segal. Role of EDHF in conduction of vasodilation along hamster cheek pouch arterioles in vivo. Am J Physiol Heart Circ Physiol 278: H1832– H1839, 2000.—We tested whether local and conducted responses to ACh depend on factors released from endothelial cells (EC) in cheek pouch arterioles of anesthetized hamsters. ACh was delivered from a micropipette (1 s, 500 nA...

... INTRODUCTION . EXPERIMENTAL First Irradiation .. Second Irradiation. CALCULATIONS ... First Irradiation. Second Irradiation. . CONCLUSIONS .•... ACKNOWLEDGEMENT . IS-184 CONTENTS 3

Rademaker, Miriam T., Vicky A. Cameron, Christopher J. Charles, Eric A. Espiner, M. Gary Nicholls, Christopher J. Pemberton, and A. Mark Richards. Neurohormones in an ovine model of compensated postinfarction left ventricular dysfunction. Am. J. Physiol. Heart Circ. Physiol. 278: H731–H740, 2000.—Clinical heart failure, often the result of myocardial infarction, may be preceded by a period of c...

Bertuglia, Silvia, and Antonio Colantuoni. Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 278: H755–H761, 2000.—Ischemia shifts the anticoaugulant/procoagulant balance of the endothelium in favor of activation of coagulation. We studied whether cheek pouch microcirculation of leukopenic hamster...