Alginate-amino acid derivatives were explored to engineer poly(DL-lactic acid)(PDL-LA) as glycocalyx-like surface to promote cell adhesion and growth. Four different kinds of alginate-amino acid derivatives were synthesized to mimic the glycocalyx of cell membrane to promote chondrogenesis. The alginate-amino acid derivatives were characterized by FT-IR, 1H NMR and UV spectra and the amino acid...

BACKGROUND AND OBJECTIVES Port-wine stains (PWSs) are capillary vascular malformations that are commonly resistant to treatment. Currently, the pulsed dye laser (PDL) is the treatment of choice. Multiple treatments are required and complete blanching after laser irradiation is rarely achieved. We review current therapeutic modalities for PWSs and recent developments for enhanced clearance. ST...

OBJECTIVE The periodontal ligament (PDL) is a fibrous connective tissue composed of heterogeneous cell types, including PDL fibroblasts. It is not clear whether cells within the PDL fibroblast population retain the potency to differentiate into other cell types. DESIGN In the present study, clonal cell lines, derived from Clawn miniature swine PDLs, were established by gene transfection for a...

This work presents three increasingly expressive Dynamic Logics in which the programs are CCS processes (sCCS-PDL, CCS-PDL and XCCSPDL). Their goal is to reason about properties of concurrent programs and systems described using CCS. In order to accomplish that, CCS’s operators and constructions are added to a basic modal logic in order to create dynamic logics that are suitable for the descrip...

Professional development and learning has a long history in seminar-like models, as well as in the more educatorpersonal delivery approaches. The question is whether an intentionally coordinated, integrated combination of the two PDL approaches will have best impacts for educators as quantified in improved student performance. Contrasts between baseline and Post-Program performance levels showe...

The periodontal ligament (PDL) is a fibrous connective tissue that exists in the cementum and the alveolar bone. Periodontitis is a chronic inflammatory disease that is caused by a bacterial infection in the periodontal region. This infection increases the production of inflammatory cytokines and causes the destruction of periodontal tissue. High mobility group box 1 (HMGB1) is a nuclear nonhis...

Gentamicin is the preferred antimicrobial agent used in implant coating for the prevention of implant-related infections (IRI). However, the present heavy local and systemic administration of gentamicin can lead to increased resistance, which has made its future use uncertain, together with related preventive technologies. Fosfomycin is an alternative antimicrobial agent that lacks the cross-re...

Bisphosphonates (BPs) such as pamidronate are used to treat bone destructive diseases and act by inhibiting bone resorption by osteoclasts, thereby improving bone quality. In contrast, BPs were shown to stimulate osteoclast formation and resorption at the mouse molar root. Periodontal ligament (PDL) fibroblasts could be seen as the mediators of osteoclast formation at this location. Here, we in...

AIM Human periodontal ligament (PDL) cells incur changes in morphology and express proteins in response to cyclic strain. However, it is not clear whether cyclic strain, especially excessive cyclic strain, induces PDL cell apoptosis and if so, what mechanism(s) are responsible. The aim of the present study was to elucidate the molecular mechanisms by which pathological levels of cyclic strain i...