API-1 (pyrido[2,3-d]pyrimidines) is a novel small-molecule inhibitor of Akt, which acts by binding to Akt and preventing its membrane translocation and has promising preclinical antitumor activity. In this study, we reveal a novel function of API-1 in regulation of cellular FLICE-inhibitory protein (c-FLIP) levels and TRAIL-induced apoptosis, independent of Akt inhibition. API-1 effectively ind...

Malignant mesothelioma (MM) is a tumor arising from mesothelium. MM patients' survival is poor. The polyphenol 4',5,7,-trihydroxyflavone Apigenin (API) is a "multifunctional drug". Several studies have demonstrated API anti-tumoral effects. However, little is known on the in vitro and in vivo anti-tumoral effects of API in MM. Thus, we analyzed the in vitro effects of API on cell proliferation,...

onychomycosis due to the yeast and yeast-like fungi was investigated among the 147 patient who refered to the mycology laboratory of school of public health during the period of 11 months. the isolated yeasts and yeast-like fungi were examined by api auxanogram methed. the distribution of isolated microorganisms were c. tropicalis 10(7.4%), c.guillioimondii & (5.9%) cases and one case of each o...

W3C XML (Extensible Markup Language) Schema defines a set of abstract components, which carry the core semantics of document structure definition. There has been no standard API for accessing these components or their structures yet. The MARKUP Technology Company has specified a Java API for accessing XML Schema and submitted it to the W3C as a possible basis for standard Schema API. An overvie...

API level vulnerabilities of hardware security modules represent a serious threat, thus, discovering and patching security holes in APIs are important. In this paper, we argue and illustrate that the application of formal verification methods is a promising approach for API analysis. In particular, we propose an API verification method based on process algebra. The proposed method seems to be e...

Interconnect Component MEM T2 HDS API Transaction Accurate Architecture T2 T3 Comm OS HAL API HDS API SystemC TLM Interconnect Component (Bus/NoC) CPU-SS1 Abstract CPU1 Periph Interface Memory Abstract CPU2 Periph Interface Memory CPU-SS2 MEM-SS T2 HDS API Comm OS HAL API T3 HAL Virtual Prototype SystemC TLM CPU-SS1 CPU1 ISS Periph Interface Memory CPU2 ISS Periph Interface Memory CPU-SS2 Inter...

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