Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We report that DP thymocytes before positive selection (preselection DP thymocytes) fail to transduce IL-7 signals even when they express high levels of transgenic IL-7R on their surface, because IL-7R si...

Associations between dietary patterns (DP) and socioeconomic factors have been little explored in adolescents. The aim of this study was to identify DP in European and Brazilian adolescents and to investigate their associations with a range of socioeconomic indicators. Adolescents from the HELENA-study and the Household Budget Survey were analyzed. Factor analysis was used to obtain DP. Linear ...

Human leukocyte antigen (HLA)-DP is considered a target for humoral immune response in clinical transplantation. This study analyses the incidence of HLA-DP antibodies in renal patients. Development and epitope specificity of donor-specific antibodies (DSA) and non-DSA (NDSA) were examined. Pre- and posttransplant sera of 338 patients were screened for HLA-DP antibodies using the luminex single...

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...

BACKGROUND AND PURPOSE Prostaglandin (PG) D(2) has emerged as a key mediator of allergic inflammatory pathologies and, particularly, PGD(2) induces leukotriene (LT) C(4) secretion from eosinophils. Here, we have characterized how PGD(2) signals to induce LTC(4) synthesis in eosinophils. EXPERIMENTAL APPROACH Antagonists and agonists of DP(1) and DP(2) prostanoid receptors were used in a model...

In this paper, we show that VC-minimal ordered fields are real closed. We introduce a notion, strictly between convexly orderable and dp-minimal, that we call dp-small, and show that this is enough to characterize many algebraic theories. For example, dp-small ordered groups are abelian divisible and dp-small ordered fields are real closed.

Dynamic Programming (DP) is an important technique used in solving optimization problems. A close correspondence between DP recurrences and Constraint Handling Rules with rule priorities (CHR) yields natural implementations of DP problems in CHR. In this work, we evaluate different implementation techniques with respect to their runtime. From our results we derive a set of guidelines for implem...

We show basic facts about dp-minimal ordered structures. The main results are: dp-minimal groups are abelian-by-finite-exponent, in a divisible ordered dp-minimal group, any infinite set has non-empty interior, and any theory of pure tree is dp-minimal.

Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions of PGD2 cannot be explained by DP alone. We show here that a seven-transmembrane receptor, CRTH2...

The main result is the prove of the linearity of the dp-rank. We also prove that the study of theories of finite dp-rank cannot be reduced to the study of its dp-minimal types and discuss the possible relations between dp-rank and VC-density.