نتایج جستجو برای: فعال کننده ی پلاسمینوژن بافتی tpa
تعداد نتایج: 196378 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Iodinated contrast agents used for computed tomography angiography (CTA) may alter fibrin fiber characteristics and decrease fibrinolysis by tissue plasminogen activator (tPA). Thromboelastography (TEG) measures the dynamics of coagulation and correlates with thrombolysis in acute ischemic stroke patients. We hypothesized that receiving CTA before tPA will not impair thro...
BACKGROUND Intravenous tissue plasminogen activator (tPA) is an effective treatment for acute ischemic stroke if administered within a few hours of stroke onset. Because of this time restriction, tPA administration remains infrequent. Ambulance use is an effective strategy for increasing tPA administration but may be influenced by geographical factors. The objectives of this study are to invest...
Inflammation, demyelination, and neurodegeneration are pathological features of multiple sclerosis (MS). In the brains of MS patients, tissue plasminogen activator (tPA) mRNA and protein are upregulated, and changes in the levels of tPA correlate with progression of the disease. However, the role of tPA in MS is as yet unknown. tPA functions in the CNS in neuronal plasticity and cell death. tPA...
برند یکی از دارایی های فکری با ارزش شرکت ها است که می تواند عملکرد بازاری شرکت را تحت تاثیر قرار دهد. شناخت برند و اثرات شخصیتی آن بر رفتار مصرف کننده می تواند به مدیران کسب و کار و بازاریابان کمک کند تا با برنامه ریزی بهتر و ایجاد برندهایی که می توانند بر اذهان مصرف کنندکان تاثیر مطلوب و مناسب تری از خود به جای بگذارند، رفتار مصرف کنندگان و مشتریان خود را به گونه ای هدایت کنند که سودآوری بیشتر...
برنداز جمله دارایی های فکری با ارزش شرکت ها است که می تواند عملکرد بازاری شرکت راتحت تأثیر قرار دهد. شناخت برند و اثرات شخصیتی آن بر رفتار مصرف کننده می تواندبه مدیران کسب و کار و بازاریابان کمک کند تا با برنامه ریزیبهتر و ایجاد برندهایی که می توانند بر اذهان مصرف کنندگان تأثیرات مطلوب و مناسب تری ازخود به جای بگذارند، رفتار مصرف کنندگان و مشتریان خود را به گونه ای هدایت کنند کهسودآوری بیشتری ب...
Tissue plasminogen activator (tPA) is an essential component of the proteolytic cascade that lyses blood clots. Various studies also suggest that tPA plays important roles in peripheral nerve regeneration. Here we show that disruption of tPA gene reduces macrophage migration after sciatic nerve injury in mice. Moreover, lack of tPA activity attenuates migrating ability of macrophages and affect...
BACKGROUND AND PURPOSE IV administration of tPA is accepted as a standard treatment for acute cerebral ischemia, but the clinical outcomes cannot be guaranteed in patients who are not recanalized after IV-tPA and in those who are not eligible for IV-tPA. In this study, outcomes from groups of patients treated with additional IA thrombolytic therapy with the use or omission of IV-tPA administrat...
Tissue type plasminogen activator (tPA) is a key enzyme in the fibrinolytic cascade. In this paper we report that tPA contains 2 independent epitopes that exert opposite effects on blood vessel tone. Low concentrations of tPA (1 nM) inhibit the phenylephrine (PE)-induced contraction of isolated aorta rings. In contrast, higher concentrations (20 nM) stimulate the contractile effect of PE. The 2...
Studies in animal models of cerebral ischemia indicate that besides its thrombolytic effect, treatment with tissue-type plasminogen activator (tPA) also induces an increase in matrix metalloproteinase-9 (MMP-9) activity in the ischemic tissue associated with the development of cerebral edema. Earlier, we had shown that the low-density lipoprotein receptor-related protein 1 (LRP1) is a substrate...
We analyzed the secretory dynamics of tissue plasminogen activator (tPA) in EA.hy926 cells, an established vascular endothelial cell (VEC) line producing GFP-tagged tPA, using total internal reflection-fluorescence (TIR-F) microscopy. tPA-GFP was detected in small granules in EA.hy926 cells, the distribution of which was indistinguishable from intrinsically expressed tPA. Its secretory dynamics...
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