The efficacy of the 5-chloro-2-methylthio-6( 1 n a p t h y l o x y ) 1H-benzimidazole called compound alpha, formulated as boluses or suspension, was evaluated against adult Fasciola hepatica in cattle. Twenty-seven steers were infected, each with 600 metacercariae of F. hepatica. After 10 weeks of infection, the animals were divided into 3 groups of 9 animals each. Group 1 received boluses at ...

OBJECTIVES The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats infected with hepatic and biliary stages of Fasciola hepatica and compared with uninfected rats after single intragastric and intravenous (iv) doses. METHODS Rats infected with F. hepatica for 25 ...

Anthelmintic resistance (AR) to Fasciola hepatica is emerging worldwide. Recently, AR to the adulticide compound albendazole (ABZ) was shown in Argentina and Spain. In Sweden, ABZ treatment failure against F. hepatica was first reported in sheep in 2012. The present study tested the efficacy of ABZ and triclabendazole (TCBZ) in sheep naturally infected with F. hepatica using a combination of th...

Red deer (Cervus elaphus) are hosts of liver fluke (Fasciola hepatica); yet, prevalence is rarely quantified in wild populations. Testing fresh samples from remote regions by faecal examination (FE) can be logistically challenging; hence, we appraise frozen storage and the use of a coproantigen ELISA (cELISA) for F. hepatica surveillance. We also present cELISA surveillance data for red deer fr...

El estudio se llevó a cabo para establecer la prevalencia e identificar los factores de riesgo asociados con las infecciones por trematodes en ganado lechero tierras altas Boyacá, Colombia. Las muestras fecales recogidas 300 bovinos seleccionados al azar examinaron utilizando una técnica sedimentación simple el recuento diferencial huevos trematodes. En estudiado fueron encontrados tres grupos ...

Background—Fascioliasis is a parasitic infection, primarily of the liver but after several weeks the biliary tract may also be aVected, related to the trematode Fasciola hepatica. The trematode is distributed worldwide in herbivores but is unusual in humans. Several outbreaks have been attributed to consumption of contaminated watercress and water. The optimal treatment of fascioliasis, particu...

With the objective of studying the role of wild fauna in the epidemiology of fasciolosis disease, a definitive wild-host inventory was carried out in a french farm where infected domestic hosts (cows) cohabit with wild potential ones. Liver flukes, faecal eggs and antibodies were looked for in lagomorphs (Oryctolagus cuniculus) and rodents (Myocastor coypus, Ondatra zybethicus, Rattus norvegicu...

introduction iran is amongst endemic countries for fasciola hepatica. individuals can become infected by consumption of contaminated uncooked green vegetables. in the chronic cases, symptoms are fever, vague abdominal pain with eosinophilia. patients sometimes have symptoms and signs of hepatobiliary involvements such as cholangitis and cholecystitis. case presentation here we present a unique ...