The adoption of the agent-based approach to the modelling and simulation of physical systems has proved to considerably increase the simulation realism and accuracy. Simulation systems of such a kind, however, require computational resources that might become unfeasible when the number of simulated agents scales up. A Distributed Simulation (DS) approach might improve the execution of such syst...

AIM Circulating concentrations of endogenous compounds such as testosterone, complicate the analysis of pharmacokinetic parameters when these compounds are administered exogenously. This study examines the influence of three correction methods of accounting for endogenous concentrations on the determination of bioequivalence between two testosterone formulations. METHODS 12 healthy males rece...

.................................................................................................................................................. 8 Zusammenfassung ................................................................................................................................ 11 1. General Introduction ...............................................................................

Transient depolarizations (TDs) appeared in canine Purkinje tissue but not in cardiac muscle during exposure to 1-2 X 10~ g/ml of acetylstrophanthidin. At low levels of toxicity, the TDs were associated with a decrease in threshold and an increase in automaticity. As intoxication progressed, the TDs coincided with transient periods of increased threshold and conduction block. Propagation from m...

In this paper we consider test statistics based on individual genotyping. For sibships without parents, but with unaffected as well as affected sibs, we introduce a new test statistic (referred to as TDS), which contrasts the allele frequency in affected sibs versus that estimated for the parents from the entire sibship. For sibships without parents, this test is analogous to the TDT and is com...

Bangalore city hosts two Urban Wastewater Treatment Plants (UWTPs) towards the periphery of Vrishabhavathi valley, located in Nellakedaranahalli village of Nagasandra and Mailasandra Village, Karnataka, India. These plants are designed and constructed with an aim to manage wastewater so as to minimize and/or remove organic matter, solids, nutrients, disease-causing organisms and other pollutant...

The testicular dysgenesis syndrome (TDS) hypothesis proposes that maldevelopment of the testis, irrespective of cause, leads to malfunction of the somatic (Leydig, Sertoli) cells and consequent downstream TDS disorders. Studies in rats exposed in utero to di(n-butyl) phthalate (DBP) have strongly supported the TDS concept, but so far no direct evidence has been produced that links dysgenesis pe...

Previous studies have indicated that salmonid fertilization success may be very sensitive to elevated concentrations of total dissolved solids (TDS) with effects at concentrations as low as 250mgl(-1) being reported. However, interpretation of these studies is complicated by poor control performance and variable concentration response relationships. To address this, a series of experiments were...

This review addresses whether there is a secular increasing trend in male reproductive developmental disorders (cryptorchidism, hypospadias, testis cancer, low sperm counts), and highlights the limitations of available data and how these issues are being addressed. These disorders are considered to represent a syndrome of disorders [testicular dysgenesis syndrome (TDS)] with a common origin in ...