Bronchiolitis obliterans (BO) is a late onset complication of allogeneic hematopoietic stem cell transplantation (HSCT), and treatment outcome is dismal if it does not respond to immunosuppressive therapy. A 21-year-old male diagnosed with acute myeloid leukemia received an allogeneic HSCT from human leukocyte antigen- identical sibling donor. Twenty one months after transplantation, he develop...

Engineering Department, Cambridge University, 9 JJ Thomson Avenue, Cambridge CB3 0FA,UK IMPMC, Universités Paris 6 et 7, CNRS, IPGP, 140 rue de Lourmel, 75015 Paris, France Department of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, UK The Born-Oppenheimer approximation (BO) [1] is the standard ansatz to describe the interaction between electrons and nuclei. BO assumes t...

Urinary tract malformations constitute the most frequent cause of chronic renal failure in the first two decades of life. Branchio-otic (BO) syndrome is an autosomal dominant developmental disorder characterized by hearing loss. In branchio-oto-renal (BOR) syndrome, malformations of the kidney or urinary tract are associated. Haploinsufficiency for the human gene EYA1, a homologue of the Drosop...

BOis isoelectronic with CN-.1 However, in comparison to CN-, which is an important ligand in inorganic and biomolecules, the chemistry of BOis relatively unknown. The electron affinity (EA) of BO (2.51 eV)2,3 is much smaller than that of CN (3.86 eV),4 which may explain the fact that CNis a stable anion in solution, but BOis not. However, the electronic structure and bond strength of BOare simi...