Stem cell division is tightly controlled via secreted signaling factors and cell adhesion molecules provided from local niche structures. Molecular mechanisms by which each niche component regulates stem cell behaviors remain to be elucidated. Here we show that heparan sulfate (HS), a class of glycosaminoglycan chains, regulates the number and asymmetric division of germline stem cells (GSCs) i...

Low complexity realizations of Least Mean Squared (LMS) error, Generalized Sidelobe Cancellers (GSCs) applied to adaptive beamforming are considered. The GSC method provides a simple way for implementing adaptive Linear Constraint Minimum Variance (LCMV) beamformers. Low complexity realizations of adaptive GSCs are of great importance for the design of high sampling rate, and/or small size and ...

Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always develop tumor recurrence. Glioblastoma stem cells (GSC), a minor subpopulation within the tumor mass, have been recently characterized as tumor-in...

Smart antenna technology is a promising means to overcome signal impairments in wireless personal communications. When spatial signal processing achieved through smart antennas is combined with temporal signal processing, the space-time processing can mitigate interference and multipath to yield higher network capacity, coverage, and quality. In this dissertation, we propose a dual smart antenn...

This study contributes to the literature on supply chain coordination by coordinating the research and development (R&D) effort, retail price, and inventory decisions. It investigates a real case in the home appliance industry. The main purpose of this study is to examine the optimal values of R&D effort, pricing, and inventory decisions under decentralized and centralized structures. Then, a d...