Patients with McArdle's myopathy lack muscle glycogen phosphorylase (M-GP) activity. Regenerating and cultured muscle of patients with McArdle's myopathy presents a glycogen phosphorylase (GP) activity, but it is not firmly established whether M-GP or non-M-GP isoforms are expressed. We have cultured myoblasts from biopsy specimen of five patients with McArdle's myopathy. Skeletal muscle was cu...

Thermosensitive injectable hydrogels based on chitosan neutralized with sodium beta-glycerophosphate (Na-β-GP) have been studied as biomaterials for drug delivery and tissue regeneration. Magnesium (Mg) has been reported to stimulate adhesion and proliferation of bone forming cells. With the aim of improving the suitability of the aforementioned chitosan hydrogels as materials for bone regenera...

The monoclonal antibody SZ1 is of interest for two reasons: it was used to define complex formation between glycoprotein (GP) Ib and GP IX, and its epitope is likely to be identical to that recognized by most quinine- and quinidine-dependent autoantibodies that cause thrombocytopenia. To determine the location of the epitope for SZ1 within the GP Ib-IX complex (which consists of three subunits:...

We describe the programming system for the graph-transformation language GP, focusing on the implementation of its compiler and abstract machine. We also compare the system’s performance with other graph-transformation systems. The GP language is based on conditional rule schemata and comes with a simple formal semantics which maps input graphs to sets of output graphs. The implementation faith...

This is the third edition of the very successful CCrISP course manual written by a multidisciplinary team of surgeons and anaesthetists. The first edition was published in 1999 and the book has been extensively updated for its third edition. However, the original aim of the course continues: that is to encourage trainees to have an understanding of the pathophysiology of critically ill patients...

The geometric process (GP) is a stochastic that was an extension of the renewal process. It introduced by Lam (1988) in 1988 with intention to model failure repairable system whose times between failures become shorter and after repairs repair longer longer. GP has been widely studied literature reliability maintenance applied optimisation policies. Some authors have proposed various versions i...

INTRODUCTION To counter a medical workforce shortage in rural and remote areas of Australia an increasing number of general practitioners are being trained in rural and remote areas. General practice (GP) registrars train in general practice as working apprentices alongside GP supervisors. GP registrars are allocated a training advisor to oversee their progress throughout their training. Centra...

By screening a chemical library for the compounds protecting cells from adriamycin (Adr), a series of small molecules was isolated that interfered with the accumulation of Adr in mouse fibroblasts by enhancing efflux of the drug. Isolated compounds also stimulated efflux of Rhodamine 123 (Rho-123), another substrate of multidrug transporters. Stimulation of drug efflux was detectable in the cel...

A glycoprotein (GP) which is immunochemically and biologically related to human prostatic acid phosphatase (PAP) has been isolated from human seminal plasma by ammonium sulfate precipitation followed by sequential concanavalin A:Sepharose 4B column, anion-exchange chromatography and gel filtration. The purified GP was shown to be homogeneous by disc- and sodium dodecyl sulfate: polyacrylamide g...