The Listeria monocytogenes surface protein InlB promotes bacterial entry into mammalian cells. Here, we identify a cellular surface receptor required for InlB-mediated entry. Treatment of mammalian cells with InlB protein or infection with L. monocytogenes induces rapid tyrosine phosphorylation of Met, a receptor tyrosine kinase (RTK) for which the only known ligand is Hepatocyte Growth Factor ...

15 Several golf greens were mapped using a RTK GPS, Riegl 3D-Laser Mirror Scanner and Trimble S6 Robotic Total Station systems to determine the most appropriate method for this task. The RTK GPS was the easiest methods for data capture but was insufficiently accurate for 20 mapping at a contour interval of 0.05 m or less in this situation. The laser scanner level data accuracy was slightly more...

During development and tissue homeostasis, cells must integrate different signals. We investigated how cell behavior is controlled by the combined activity of transforming growth factor-beta (TGF-beta) and receptor tyrosine kinase (RTK) signaling, whose integration mechanism is unknown. We find that RTK/Ras/MAPK (mitogen-activated protein kinase) activity induces p53 N-terminal phosphorylation,...

Most growth factors control cellular functions by activating specific receptor tyrosine kinases (RTKs). While overactivation of RTK signalling pathways is strongly associated with carcinogenesis, it is becoming increasingly clear that impaired deactivation of RTKs may also be a mechanism in cancer. A major deactivation pathway, receptor downregulation, involves ligand-induced endocytosis of the...

The integration of global navigation satellite system (GNSS) single-frequency (SF) real-time kinematics (RTKs) and inertial (INS) has the advantages low-cost low-power consumption compared to multiple-frequency GNSS RTK/INS system. However, due vulnerability signal reception, application SF-RTK/INS is limited in complex environments. To improve positioning accuracy GNSS-blocked environments, we...

Global navigation satellite system real-time kinematic (GNSS-RTK) positioning is an indispensable source for providing absolute autonomous driving vehicles (ADV), due to its high accuracy when a fixed solution achieved. Satisfactory can be obtained in open areas. However, the performance of GNSS-RTK significantly degraded by signal reflections from buildings, causing multipath effects and non-l...

PURPOSE This study investigated whether mutations of receptor tyrosine kinase (RTK) genes detected using next-generation sequencing (NGS) are suitable therapeutic targets. EXPERIMENTAL DESIGN Fifty surgically resected non-small cell lung cancer (NSCLC) samples were target resequenced using NGS. We then investigated the functions of the identified RTK gene mutations, including their oncogenic ...

Endothelial progenitor cells (EPCs) repair damaged endothelium and promote capillary formation, processes involving receptor tyrosine kinases (RTKs) and heme oxygenase 1 (HO-1). Because estradiol augments vascular repair, we hypothesize that estradiol increases EPC proliferation and capillary formation via RTK activation and induction of HO-1. Physiological concentrations of estradiol (10 nmol/...

Up to now, several clinical studies have been started investigating the relevance of receptor tyrosine kinase (RTK) inhibitors upon progression free survival in various pediatric brain tumors. However, single targeted kinase inhibition failed, possibly due to tumor resistance mechanisms. The present study will extend our previous observations that vascular endothelial growth factor receptor (VE...

Endothelial progenitor cells (EPCs) repair damaged endothelium and promote capillary formation, processes involving receptor tyrosine kinases (RTKs) and heme oxygenase 1 (HO-1). Because estradiol augments vascular repair, we hypothesize that estradiol increases EPC proliferation and capillary formation via RTK activation and induction of HO-1. Physiological concentrations of estradiol (10 nmol/...