Two-dimensional materials, such as graphene and monolayer hexagonal BN (h-BN), are attractive for demonstrating fundamental physics in materials and potential applications in next-generation electronics. Atomic sheets containing hybridized bonds involving elements B, N and C over wide compositional ranges could result in new materials with properties complementary to those of graphene and h-BN,...

MVA-BN-PRO (BN ImmunoTherapeutics) is a candidate immunotherapy product for the treatment of prostate cancer. It encodes 2 tumor-associated antigens, prostate-specific antigen (PSA), and prostatic acid phosphatase (PAP), and is derived from the highly attenuated modified vaccinia Ankara (MVA) virus stock known as MVA-BN. Past work has shown that the immunogenicity of antigens can be improved by...

For p > 0, let B(Bn) and Lp(Bn) respectively denote the p-Bloch and holomorphic p-Lipschitz spaces of the open unit ball Bn in C . It is known that B(Bn) and L1−p(Bn) are equal as sets when p ∈ (0, 1). We prove that these spaces are additionally norm-equivalent, thus extending known results for n = 1 and the polydisk. As an application, we generalize work by Madigan on the disk by investigating...

BN rats develop interstitial nephritis after immunization with rabbit, but not rat renal tubular antigen. Using RT1n rat strains that differentially express tubular antigen, we investigated the unresponsiveness of BN rats to BN tubular antigen (BN-TBM) using delayed-type hypersensitivity (DTH) responses to BN-TBM as a measure of cell-mediated immunity. Our results indicate that rat strains expr...

A set of n triangles sharing a common edge is called a book with n pages and is denoted by Bn. It is known that the Ramsey number r (Bn) satisfies r (Bn) = (4 + o (1))n. We show that every red-blue edge coloring of Kb(4−ε)nc with no monochromatic Bn exhibits quasi-random properties when ε tends to 0. This implies that there is a constant c > 0 such that for every red-blue edge coloring of Kr(Bn...

The mechanisms regulating receptor internalization are not well understood and vary among different G protein-coupled receptors. The bombesin (Bn)/gastrin-releasing peptide receptor GRP-R, which is coupled to phospholipase C via the Gq family of transducing proteins, is internalized rapidly after Bn binding. Agonist stimulation leads to rapid receptor phosphorylation, as does activation of prot...

The extracellular portion of the granulocyte colony-stimulating factor (G-CSF) receptor has a mosaic structure of six domains (each approximately 100 amino acid residues) consisting of an immunoglobulin-like (Ig) domain, a cytokine receptor homologous region subdivided into amino-terminal (BN) and carboxyl-terminal (BC) domains, and three fibronectin type III repeats. In the present study, we e...

Bombesin/gastrin releasing peptide (BN/GRP) functions as an auto crine growth factor in small cell lung cancer (SCLC). Previously, this autocrine growth cycle was disrupted by a monoclonal antibody which binds to the carboxyl terminal of BN and neutralizes the peptide so that it is unable to interact with the BN/GRP receptor. Here a series of BN analogues were synthesized which have a reduced p...