The analytical performance and the clinical utility of a thyrotropin receptor (TSHR)-stimulating immunoglobulin (TSI) bioassay were compared with those of a TSHR-binding inhibitory immunoglobulin (TBII) assay. Limits of detection (LoD) and quantitation (LoQ), assay cutoff, and the half-maximal effective concentration (EC(50)) were measured. Dilution analysis was performed in sera of hyperthyroi...

OBJECTIVE To report a case of vaccine-induced Graves' disease successfully managed with L-carnitine and propranolol and without antithyroid drugs (ATDs). ATDs sometimes need to be used at low doses or can be contraindicated/refused. One of the ancillary compounds available is L-carnitine. L-carnitine is a naturally occurring quaternary amine, which acts by impairing thyroid hormone access to th...

We studied whether common polymorphisms in genes involved in folate metabolism affect methotrexate (MTX) sensitivity. Ex vivo MTX sensitivity of lymphoblasts obtained from pediatric patients with acute lymphoblastic leukemia (ALL; n = 157) was determined by the in situ thymidylate synthase inhibition assay after either continuous (21 hours; TSI(50, cont)) or short-term (3 hours; TSI(50, short))...

BACKGROUND Established methods to determine asynchrony suffer from high intra- and interobserver variability and failed to improve patient selection for cardiac resynchronization therapy (CRT). Thus, there is a need for easy and robust approaches to reliably assess cardiac asynchrony. METHODS AND RESULTS We performed echocardiography in 100 healthy subjects and 33 patients with left bundle br...

The purpose of this research is to adapt the Teaching Style for Successful Intelligence Questionnaire (TSI-Q) developed by Paloş and Maricutoui (2006) Turkish. was carried out on three separate groups consisting 305 high school teachers. In linguistic equivalence study, it obtained that there were strong, positive, significant correlations between responses participants English Turkish forms sc...

The current study deals with the physicochemical characterization, temporal variability and trophic state evaluation of a post glacial mountain lake in eastern Himalaya during the period of 2014-2016. Notable seasonal variations are recorded for physicochemical parameters of lake water. The values for electrical conductivity, total suspended solids, total dissolved solids, total alkalinity and ...

Purpose It is still equivocal whether oxygen uptake recovery kinetics are limited by oxygen delivery and can be improved by supplementary oxygen. The present study aimed to investigate whether measurements of muscle and pulmonary oxygen uptake kinetics can be used to assess oxygen delivery limitations in healthy subjects. Methods Sixteen healthy young adults performed three sub-maximal exerci...

Tissue spray ionization mass spectrometry (TSI-MS) directly on small tissue samples has been shown to provide highly specific molecular information. In this study, we apply this method to the analysis of 38 pairs of human lung squamous cell carcinoma tissue (cancer) and adjacent normal lung tissue (normal). The main components of pulmonary surfactants, dipalmitoyl phosphatidylcholine (DPPC, m/z...

While organizations in software industry want to portray themselves as professional in terms of following standards and methods, they may also have needs for improvising and short-cutting when necessary. Such dilemmas of dual logics are sometimes internally resolved by evolving a false belief of what is done (practice) being in correspondence to what is said (standards), regardless of what an e...