Although the peptide somatostatin (SST) has been speculated to function in temporal lobe epilepsy, its exact role is unclear, as in vivo studies have suggested both pro- and anticonvulsant properties. We have shown previously that SST has multiple inhibitory cellular actions in the CA1 region of the hippocampus, suggesting that in this region SST should have antiepileptic actions. To directly a...

Normal and tumoral pituitary corticotropic cells express sst 2 and sst 5 , of which sst 5 is the predominantly expressed receptor subtype. Somatostatin (SS) inhibits pituitary adrenocorticotropin hormone (ACTH) secretion in vitro, but the sensitivity to SS is strongly regulated by glucocorticoids. In pathological conditions of a low endogenous cortisol level, i.e. in patients with adrenal insuf...

Excessive excitation or loss of inhibitory neurotransmission has been closely related to epileptic activity. Somatostatin (SST) and Neuropeptide Y (NPY) are members of endogenous neuropeptides which are recognized as important modulator of classical neurotransmitter, distributed abundantly in mammalian central nervous system. Abnormal expression of these two neuropeptides evidenced in some epil...

Neuroendocrine tumours (NETs) may occur at many sites in the body although the majority occur within the gastroenteropancreatic axis. Non-gastroenteropancreatic NETs encompass phaeochromocytomas and paragangliomas, medullary thyroid carcinoma, anterior pituitary tumour, broncho-pulmonary NETs and parathyroid tumours. Like most endocrine tumours, NETs also express somatostatin (SST) receptors (s...

[1] Six years of daily satellite data are used to quantify and map intraseasonal variability of chlorophyll and sea surface temperature (SST) in the California Current. We define intraseasonal variability as temporal variation remaining after removal of interannual variability and stationary seasonal cycles. Semivariograms are used to quantify the temporal structure of residual time series. Emp...

[1] This study shows that the SST variations in the July– August–September (JAS) peak season of the Atlantic Warm Pool (AWP) are modulated by the air-sea fluxes. This feature is captured in the correlations between the rainfall and SST, and rainfall and SST tendency in the multi-decadal integration of the National Centers for Environmental Prediction (NCEP) Climate Forecast System (CFS). Likewi...

The EST data provide a powerful tool for identi cation of transcribed DNA sequences. However, since ESTs are relatively short, many exons are poorly covered by ESTs thus reducing the utility of EST data. Recently, SST (Signature Sequence Tags) ngerprints were proposed as an alternative to EST ngerprints. Given a ngerprint set of probes, SST of a clone is a subset of probes from the ngerprint se...

Annual natural discharge (Q) of the River Murray and its most extensive tributary, the Darling River system, is often inversely related to sea surface temperature (SST) anomalies in the eastern tropical Pacific Ocean. These SST variations are components of a planetary-scale phenomenon referred to as E1 Nino-Southern Oscillation (ENSO). Darling and Murray river historical values of Q indicate th...

A computer-based Spoken Spanish Test (SST) was developed to provide an accurate and convenient assessment of speaking and listening for learners of Spanish. The SST is intended to measure a candidate’s receptive familiarity with a variety of forms of Spanish and the candidate’s facility in speaking Spanish. The SST test takes between 15 and 20 minutes to complete, all the items are presented in...

Tropical cyclone rainfall rates have been projected to increase in a warmer climate. The area coverage of tropical cyclones influences their impact on human lives, yet little is known about how tropical cyclone rainfall area will change in the future. Here, using satellite data and global atmospheric model simulations, we show that tropical cyclone rainfall area is controlled primarily by its e...