adioiodine (RAI) therapy for metastatic follicular cell–derived thyroid cancer (FCDC) requires elevated levels of serum TSH, usually achieved by withdrawal of thyroxine therapy. This is not possible in FCDC associated with hypopituitarism, because of the absence of endogenous TSH. However, the advent of recombinant human TSH (rhTSH) has made diagnostic 131I whole body scans and subsequent RAI t...

BACKGROUND Synovial sarcomas are uncommon malignancies that mainly affect adolescents and young adults. Most arise from the deep soft tissues of the extremities, but they can occur in other parts of the body such as the lung. Synovial sarcomas after radiation therapy are rare, in contrast with other sarcomas, with only six reported cases. Secondary malignancies after radioactive iodine (RAI) th...

Because tumor progression is angiogenesis-dependent, angiogenesis density was investigated by immunohistochemistry and computed image analysis in bone marrow (BM) biopsies of 45 newly diagnosed patients with Binet stage A B-cell chronic lymphocytic leukemia (BCLL) and correlated to upstaging and progression-free survival during a 40-month follow-up period. Their microvessel areas and counts wer...

With this letter, Mitsubishi Heavy Industries, Ltd. ("MHI1") transmits to the U.S. Nuclear Regulatory Commission ("NRC") a document entitled "Response to Request for Additional Information No. 211-1946, Revision 1." Enclosed are the responses to 3 RAIs contained within Reference 1. Of these RAIs in Reference 1, 4 will not be answered within this package. They are: RAI 3.7.1-3, which has a 60-da...

To examine outbreaks of mange in raccoon dogs (Nyctereutes procyonoides) with respect to population density, we analyzed camera trap videos, and isolated mites from raccoon dog carcasses. In a camera trapping survey, we categorized the skin condition of raccoon dogs, and used a number of independent videos to calculate the relative abundance index (RAI). The RAI of raccoon dogs with alopecia in...

Leading thyroidologists in the United States and in Europe have most frequently recommended radioiodine (RAI) therapy when elimination of a solitary toxic nodule is indicated (1, 2). Interdisciplinary guidelines in Germany, authorized by the national associations of nuclear medicine, endocrinology and surgery, also give RAI administration as the therapy of choice for this indication (3). How th...

Purpose: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats. Methods: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of 3 mCi of 131I and 1 mL physiologic saline for 7 days by gastric gavage, and a zinc group (n=20), whic...

BACKGROUND Patient decision aids (P-DAs) are used to inform patients about healthcare choices, but there is limited knowledge about their longer term effects, beyond the time period of decision-making. METHODS/DESIGN We developed a computerized P-DA that explains the choice of radioactive iodine (RAI) adjuvant treatment or no RAI, for patients with low risk papillary thyroid cancer after tota...

IMPORTANCE Graves disease is the most common cause of persistent hyperthyroidism in adults. Approximately 3% of women and 0.5% of men will develop Graves disease during their lifetime. OBSERVATIONS We searched PubMed and the Cochrane database for English-language studies published from June 2000 through October 5, 2015. Thirteen randomized clinical trials, 5 systematic reviews and meta-analys...