PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in various tumor cell lines. There has been virtually no tissue study on the expression of PLZF in prostate cancer (PCa). PCa is a heterogeneous disease, most of which are indolent and non-lethal. Currently there are no biomarkers that distinguis...

The first advance in the history of studies on prostate cancer (PCa) and androgens was the development of treatment with castration and administration of estrogen by Charles B. Huggins, who won the Nobel Prize in Physiology and Medicine. Since then, and for 70 years, androgen deprivation therapy has been the standard therapy for advanced PCa and the center of studies on PCa. However, recent adv...

The dysregulation of miR‑126 has been reported to correlate with the progression of several cancer types. The present study demonstrated that miR‑126 was significantly downregulated in prostate cancer (PCa) tissues compared with normal prostate tissues. In vitro and in vivo studies indicated that forced overexpression of miR‑126 significantly suppressed the proliferation of PCa cell lines. Addi...

Robust PCA methods are typically based on batch optimization and have to load all the samples into memory during optimization. This prevents them from efficiently processing big data. In this paper, we develop an Online Robust PCA (OR-PCA) that processes one sample per time instance and hence its memory cost is independent of the number of samples, significantly enhancing the computation and st...

BACKGROUND Prostate cancer (PCa) is the most commonly diagnosed cancer and kills about 28,000 American men annually. Although progress has been made in understanding the molecular features of different forms of the disease, PCa is considered incurable when it becomes resistant to standard therapies. Prostate specific antigen (PSA) test has been a gold standard of diagnosis for PCa, however, it ...

The method of sparse principal component analysis (S-PCA) proposed by Zou, Hastie, and Tibshirani (2006) is an attractive approach to obtain sparse loadings in principal component analysis (PCA). S-PCA was motivated by reformulating PCA as a least-squares problem so that a lasso penalty on the loading coefficients can be applied. In this article, we propose new estimates to improve S-PCA in the...

Nuclear receptors are important to maintain the tissue homeostasis. Each receptor is tightly controlled and under a very complicated balance. In this review, we summarize the current findings regarding the nuclear receptor TR4 and its role in prostate cancer (PCa) progression. In general, TR4 can inhibit the PCa carcinogenesis. However, when PPARγ is knocked out, activation of TR4 can have an o...

The purpose of this study was to analyze and characterize the clinicopathological features of incidental prostate cancer (PCa) after radical cystoprostatectomy (RCP) for bladder cancer in Chinese patients. We retrospectively reviewed 378 male patients who underwent RCP for muscle invasive bladder cancer at our center and identified 47 men with incidental PCa. The clinicopathological data of inc...

INTRODUCTION The purpose of this in vitro study was to determine whether para-chloroaniline (PCA) is formed through the reaction of mixing sodium hypochlorite (NaOCl) and chlorhexidine (CHX). METHODS Initially, commercially available samples of chlorhexidine acetate (CHXa) and PCA were analyzed with 1H nuclear magnetic resonance (NMR) spectroscopy. Two solutions, NaOCl and CHXa, were warmed t...

background: prostate cancer (pca) is an important health problem in the aging male population in the world. it is the third most common cancer in the world. despite of its importance, relatively little is known about its etiology. sexually transmitted infections (sti) and urogenital pathogens such as mycoplasma and ureaplasma, have been proposed as a risk factor for prostate cancer development....