نتایج جستجو برای: شاخص cpt

تعداد نتایج: 79993  

Journal: :Regenerative biomaterials 2015
Si-Yong Qin Meng-Yun Peng Lei Rong Bin Li Shi-Bo Wang Si-Xue Cheng Ren-Xi Zhuo Xian-Zheng Zhang

Camptothecin (CPT)-based drugs always undergo the reversible, pH-dependent lactone ring-opening reaction, yielding the inactive but toxic carboxylate form. Self-assembly strategy provides an effective route for preserving their bio-stability. In this article, nano-sized self-assemblies from CPT-based antitumor drugs were simply built up by directly diluting the stock dimethylsulfoxide solutions...

2016
Hisham A Abou-Taleb Masafumi Koshiyama Noriomi Matsumura Tsukasa Baba Ken Yamaguchi Junzo Hamanishi Kaoru Abiko Koji Yamanoi Ryusuke Murakami Naoki Horikawa Ahmed AA Taha Sachiko Kitamura Ikuo Konishi

OBJECTIVE To investigate the clinical efficacy of neoadjuvant chemotherapy (NAC) with irinotecan (CPT-11) and nedaplatin (NED) followed by radical hysterectomy. METHODS Patients with locally advanced cervical cancer (stage Ib2-IIb) were treated with NAC followed by surgery, primary surgery or primary radiotherapy. NAC was usually performed using transuterine arterial chemotherapy (TUAC) or in...

2005
Nick E. Mavromatos

Invariance under the combined transformations of CPT (in any order) is guaranteed in Quantum Field Theory in flat space times due to a basic theorem (CPT Theorem). The currently used formalism of particle physics phenomenology is based on this theorem. However, there may be violations of the basic underlying assumptions of this theorem in models of quantum gravity, namely Lorentz covariance, un...

2014
Seong-Joon Lee Young-Sil An Tae Sung Lim So Young Moon

BACKGROUND [corrected] We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to ex...

2013
Enrica L. Santarcangelo Giulia Paoletti Iacopo Chiavacci Carlo Palombo Giancarlo Carli Maurizio Varanini

In healthy subjects with high hypnotisability (highs) under hypnosis, subjectively effective suggestions for analgesia abolish the increases in blood pressure associated with cold pressor test (cpt) by reducing the peripheral vascular resistance. The aim of the present study was to investigate the effects of the suggestions of analgesia on the responses to cpt in healthy highs (n = 22) and in l...

Journal: :Molecular pharmacology 1999
P Fiorani J F Amatruda A Silvestri R H Butler M A Bjornsti P Benedetti

DNA topoisomerase I (Top1p) relaxes supercoiled DNA by the formation of a covalent intermediate in which the active site tyrosine is transiently bound to the severed DNA strand. The antineoplastic agent camptothecin (Cpt) specifically targets Top1p and several mutations have been isolated that render the enzyme Cpt resistant. The mutated residues, although located in different regions of the en...

Journal: :Journal of Physics: Conference Series 2013

Journal: :Modern Physics Letters A 2010

Journal: :The European Physical Journal C 2013

Journal: :Materials 2023

A glioma is the most common malignant primary brain tumor in adults and categorized according to its growth potential aggressiveness. Within gliomas, grade 4 glioblastoma remains one of lethal solid tumors, with a median survival time less than 18 months. By encapsulating CPT-11 oleic acid-coated magnetic nanoparticles (OMNPs) poly(lactic-co-glycolic acid) (PLGA) nanoparticles, we first prepare...

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