A cyclic molecule including a hexameric PNA sequence has been designed and synthesized in order to target the TAR RNA loop of HIV-1 through the formation of a "kissing complex". For comparison, its linear analogue has also been investigated. The synthesis of the cyclic and linear PNA has been accomplished following a liquid-phase strategy using mixed PNA and fully N-protected (aminoethylglycina...

The preparation of t-butoxycarbonyl (Boc)-protected O(4)-(o-nitrophenyl) thymine peptide nucleic acid (PNA) monomer is described. This PNA monomer was incorporated into PNA oligomer sequences. The post-synthetic modification of the oligomers to yield fluorescently-labelled PNA oligomers was studied before and after the removal of the protecting groups. In both cases, the desired fluorescently-l...

This letter investigates hot-carrier-induced degradation on 0.1 m partially depleted silicon-on-insulator (SOI) nMOSFETs at various ambient temperatures. The thermal impact on device degradation was investigated with respect to body-contact nMOSFETs (BC-SOI) and floating-body SOI nMOSFETs (FB-SOI). Experimental results show that hot-carrier-induced degradation on drive capacity of FB-SOI device...

Abstarct The work presents the newly deploying technology in semiconductor industry called silicon on insulator (SOI). Its two technology partially and fully depleted SOI and describe how these are different from conventional bulk MOS technology, advantages over bulk technology and floating body effect of PD/FD SOI technology, factors effecting floating body such as kink effects in PD SOI, para...

The Medieval Climate Anomaly (MCA) was the most recent pre-industrial era warm interval of European climate, yet its driving mechanisms remain uncertain. We present here a 947-year-long multidecadal North Atlantic Oscillation (NAO) reconstruction and find a persistent positive NAO during the MCA. Supplementary reconstructions based on climate model results and proxy data indicate a clear shift ...

This paper analyze the soft error tolerance related to layout structures on 65-nm bulk and SOI processes. The layout structure in which well contacts are placed between redundant latches suppresses MCU effectively. Also the tolerance of SOI structure transistor is estimated by TCAD simulations. The charge collection mechanism is suppressed by the BOX (Buried Oxide) in SOI transistor. Charge sha...

The to equation method based on an equivalent isobaric geopotential height in t• coordinates has been used to retrieve the precipitation over Greenland. This approach is designed to accurately represent the topographic effects of the Greenland Ice Sheet on atmospheric motion and precipitation. The 11 year mean precipitation from 1985 to 1996 over all of Greenland is 376 mm yr -• which is close ...

We have used dialyzed squid axons to characterize the ouabain- and bumetanide-insensitive Na efflux components and their relation to the operation of the Na/Ca exchange mechanism. In axons dialyzed with solutions containing nearly physiological concentrations of K, Na, and Mg, three components of the Na efflux can be distinguished: Cai-activated, Cao-dependent Na efflux ("reverse" Na/Ca exchang...

Lymphocyte proliferation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is inhibited by agents known to induce differentiation in murine erythroleukemia cells and other cell lines. In the present study, we determined the cellular targets for the action of TPA among murine thymocyte subpopulations, the phase of blastogenesis that is activated by the tumor promoter, and ...