Sarcomere maintenance, the continual process of replacement of contractile proteins of the myofilament lattice with newly synthesized proteins, in fully differentiated contractile cells is not well understood. Adenoviral-mediated gene transfer of epitope-tagged tropomyosin (Tm) and troponin I (TnI) into adult cardiac myocytes in vitro along with confocal microscopy was used to examine the incor...

We describe the adoption of high sensitive troponin I (hsTnI) in clinical practice in two hospital settings in Italy. Samples from 426 consecutive patients (mean age 68.8 ± 17.0) admitted to the Emergency Department with a suspected acute coronary syndrome (ACS) have been tested at admittance and after 3 and 6 hours by contemporary TnI and hsTnI. Results have been compared to the final clinical...

Most of the current docking procedures are focused on fine conformational adjustment of assembled complexes and fail to reproduce large-scale motions. Our approach based on the coarse-grained modeling of flexible macromolecules ov ercomes t hese limitations. CA BSDock proc edure us ed in t his work employs c oarse-grained m odel CA BS – efficient and v ersatile t ool for modeling of proteins st...

This study aims to determine the interaction and communication patterns of Persit-KCK (Army Wives Association) organization that have an impact on harmony cohesiveness among members build a strong commitment providing benefits wider community in Indonesia. also increases loyalty every soldier Indonesian National Armed Forces (TNI-AD) their responsibility for upholding state sovereignty, maintai...

Este estudo analisou a formação de treinadores nível nacional e internacional goalball quanto aos contextos formais aprendizagem. A amostra foi composta por 81 esportivos provenientes 23 países dividida em dois grupos: o primeiro composto 47 Treinadores Nível Nacional (TNN) segundo 34 Internacional (TNI). Para análise das questões múltipla escolha, utilizada estatística descritiva com média ± D...

BACKGROUND Many blood biomarkers have a positive association with stroke outcome, but adding blood biomarkers to the National Institutes of Health Stroke Scale (NIHSS) did not significantly improve its discriminatory ability. We investigated the association of the CHA2DS2-VASc score with unfavourable functional outcome (defined as a 30-day modified Rankin Scale [mRS] ≥ 3) in patients presenting...

We report on variational calculations of the energy E(p, ß) of asymmetric nuclear matter having p = p +pp = 0.05 to 0 .35 fm-~, and ß = (P -p~)lp = 0 to l . The nuclear hamiltonian used in this work consists of a realistic two-nucleon interaction, called °i<, that fits the available nucleon-nucleon scattering data up to 425 MeV, and a phenomenological three nucleon interaction adjusted to repro...

tion. We believe that this change will significantly increase the sensitivity for detecting myocardial necrosis (1, 3). In summary, we have shown that the upper reference limit for a healthy population is 0.16 g/L for TnI concentrations measured using the Bayer ACS:Centaur method. The difference between TnI values obtained for serum or heparin-plasma specimens is only just significant at the lo...

Featured Article: Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin I and preliminary results in suspected cases of myocardial infarction. Clin Chem 1992;38:2203–14. In the early 1980s, David N. Dietzer and I started building a team to develop monoclonal antibodies to the isoenzymes then used for detecting cardiac damage: creatine ki...