This report evaluates the efficiency and safety of catheter-directed thrombolysis (CDT) using tissue plasminogen activator (tPA) and argatroban for the treatment of IVC filter thrombosis complicated by heparin-induced thrombocytopenia (HIT). From October 2012 to December 2014, 19 patients with unilateral lower extremity deep venous thrombosis were treated with standard anticoagulation, filter p...

Delaunay Triangulation (DT) and its extension Constrained Delaunay Triangulation (CDT) are spatial data structures that have wide applications in spatial data processing. Our recent survey shows, however, that there is a surprising lack of algorithms for computing DT/CDT for large spatial databases. In view of this, we propose an efficient algorithm based on the divide and conquer paradigm. It ...

A test was constructed by combining carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (GT) and was evaluated in detecting alcohol-dependent patients in a surgical ward. The performance of the combined test was significantly better than that of either %CDT alone or GT alone, as evaluated by calculating sensitivity and likelihood ratio at a specificity of 0.85 and by compari...

Many bacterial pathogens encode the cytolethal distending toxin (CDT), which causes host cells to arrest during their cell cycle by inflicting DNA damage. CDT is composed of three proteins, CdtA, CdtB, and CdtC. CdtB is the enzymatically active or A subunit, which possesses DNase I-like activity, whereas CdtA and CdtC function as heteromeric B subunits that mediate the delivery of CdtB into hos...

Stimulus-like properties of the 2f1-f2 cubic difference tone (CDT) were examined by determining whether a binaural masking-level difference (BMLD) could be obtained for a 500-Hz physical tone to one ear and a CDT of the same frequency to the other ear. Masked thresholds for the physical tone (signal) were obtained as the phase of this tone varied through 360 degrees relative to harmonically rel...

OBJECTIVES Clostridium difficile produces toxins and is an aetiological organism of pseudomembranous colitis. Immunoglobulin is one of the treatment strategies against fulminant C. difficile infections, but the clinical evidence is still limited. We examined the efficacy of intravenous immunoglobulin (IVIg) in C. difficile toxin (CDT)-mediated lethality and cellular injury in mice. METHODS Mi...

Causal Dynamical Triangulations (CDT) provide a non-perturbative formulation of Quantum Gravity assuming the existence of a global time foliation. In our earlier study we analyzed the effect of including d copies of a massless scalar field in the two-dimensional CDT model with imaginary time. For d > 1 we observed the formation of a “blob”, somewhat similar to that observed in four-dimensional ...

Despite the wide use of clock drawing tests (CDTs) for screening cognitive impairment, their use in patients having Parkinson disease (PD) with dementia has not been systematically investigated until date. In this cross-sectional study, neurological and neuropsychiatric statuses of 1449 outpatients having PD with and without dementia were comprehensively assessed. The CDT revealed cognitive imp...

Binary toxin (CDT) is frequently observed in Clostridium difficile strains associated with increased severity of C. difficile infection (CDI). CDT belongs to the family of binary ADP-ribosylating toxins consisting of two separate toxin components: CDTa, the enzymatic ADP-ribosyltransferase which modifies actin, and CDTb which binds to host cells and translocates CDTa into the cytosol. CDTb is a...