OBJECTIVE To estimate the association of the estrogen and progestin potency of combined oral contraceptive pills (OCPs) with epithelial ovarian carcinoma risk. METHODS This population-based case-control study included 745 women with incident, histologically confirmed epithelial ovarian carcinoma and 943 controls, matched on age and ethnicity. Data were collected using a standard questionnaire...

Bone surfaces attract hematopoietic and nonhematopoietic cells, such as osteoclasts (OCs) and osteoblasts (OBs), and are targeted by bone metastatic cancers. However, the mechanisms guiding cells toward bone surfaces are essentially unknown. Here, we show that the Gαi protein-coupled receptor (GPCR) EBI2 is expressed in mouse monocyte/OC precursors (OCPs) and its oxysterol ligand 7α,25-dihydrox...

Abstract Trace residues of organochlorine pesticides (OCPs) in estuarine surface sediments were investigated at three protected wetlands southern Taiwan using high‐resolution gas chromatography/high‐resolution mass spectrometry (HRGC/HRMS) and chromatography‐electron capture detector (GC‐ECD). This study facilitates the development new strategies for investigating OCPs, particularly background ...

Objective. The capillary gas chromatographic method was introduced for determining organochlorine pesticide residues (OCPs) in traditional Chinese medicines: Gastrodia Tuber, Fructus Corni and Spica Prunellae. Methods. The organochlorine pesticides were extracted from herbs with mixed solvents (petroleum ether), cleaned up by concentrated HzSO4, and separated by capillary column with electron c...

Recent years have seen an upsurge of interest in developing low cost and reliable methods for the detection and precise determination of ultra-trace concentrations of persistent organic pollutants (POPs), because of their bioaccumulation, transformation and toxicity. Therefore, a comprehensive review with 108 references referring to the distribution, source, accumulation, transformation, types ...

Melasma is a common acquired hypermelanosis of the skin that has been associated with several etiologic factors including ultraviolet light exposure, pregnancy, and oral contraceptives (OCPs) (1). Forty-one percent of women surveyed in one study had onset of melasma after pregnancy, and 25% after starting an OCP (2). Women who develop melasma during pregnancy may be more susceptible to developi...

Primary dysmenorrhea is painful menstrual cramps without any evident pathology to account for them, and it occurs in up to 50% of menstruating females and causes significant disruption in quality of life and absenteeism. Current understanding implicates an excessive or imbalanced amount of prostanoids and possibly eicosanoids released from the endometrium during menstruation. The uterus is indu...

Fifty-six representative samples of topsoil were collected around Guanting Reservoir, which is an important water source for Beijing. Concentrations of the insecticides HCH, DDT, and their metabolites were quantified by use of gas chromatography (GC) with electron capture detection (ECD). Organochlorine pesticides (OCPs) are still present in surface soils in the Guanting area. DDT accounts for ...

OBJECTIVES Use of oral contraceptive pills (OCP) increases the risk of cerebral venous sinus thrombosis (CVST). Whether this risk varies by type, duration, and other forms of hormonal contraceptives is largely unknown. This systematic review and meta-analysis update the current state of knowledge. METHODS We performed a search to identify all published studies on the association between hormo...