What is the DGVa? The Database of Genomic Variants archive [2] (DGVa) is a public catalogue of structural variation found in the genomes of individuals within a species. Why do we need the DGVa? In recent years there have been unprecedented advances in the technologies that characterise genomic variation, and it is well known that variation at the single nucleotide level is abundant across the ...

Quantum mechanics is a mathematical model of the physical world, which is built on a small number of postulates, each of which makes a particular claim on how the model reflects physical reality. All the rest of the theory can be derived from these postulates, but the postulates themselves cannot be proved in the mathematical sense. One has to make experiments and see whether the predictions of...

ChEBI [3], EMBL-EBI’s database of Chemical Entities of Biological Interest, is a freely available, manually annotated database of small molecular entities (molecules not encoded by the genome, Figure 1). These could include any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion [4], complex, conformer [5], or anything else that is a separately distingu...

Main library for Southern Illinois University Carbondale [2] Holds more than 2.6 million volumes, 200,000 e-books, 43,000 current periodicals and serials, and over 3.6 million microform units Provides access to I-Share [3] (the statewide automated library system) and to a comprehensive array of databases and other electronic data files Offers a wide range of services, including Reference assist...

The paper advocates the use of a statistical tool dedicated to the exploration of data samples populated by several sources of events. This new technique, called sP lot, is able to unfold the contributions of the different sources to the distribution of a data sample in a given variable. The sP lot tool applies in the context of a Likelihood fit which is performed on the data sample to determin...

The BioSamples Database aggregates information for reference samples (such as cell lines or stock strains), as well as samples for which data exist in one of the EBI's other data resources (e.g. ArrayExpress [2], the European Nucleotide Archive [3], PRIDE [4]). Samples are described with a set of annotations. These annotations can be linked to ontology [5] (or controlled vocabulary [6]) terms, ...

Main library for Southern Illinois University Carbondale [2] Holds more than 2.6 million volumes, 200,000 e-books, 43,000 current periodicals and serials, and over 3.6 million microform units Provides access to I-Share [3] (the statewide automated library system) and to a comprehensive array of databases and other electronic data files Offers a wide range of services, including Reference assist...

Why do we need EMPIAR? EMPIAR provides a way to easily access state-of-the-art 2D image data that underpins 3D cryo-EM structures of biomacromolecules [6] and molecular machines. It complements the Electron Microscopy Data Bank (EMDB [7]), where corresponding 3D structures are stored, and PDB [8] which stores atomic models of macromolecular structures (Figure 1). EMPIAR data has been used to fa...

Classifying proteins into families and identifying important domains and sites is invaluable for helping biologists to identify distantly related proteins and to predict their functions. A daunting array of resources, each with different strengths and weaknesses, is now available for searching genomes and proteomes with ‘protein signatures’ – diagnostic entities that are used to recognise a par...