Patients with chronic obstructive pulmonary disease (COPD) show impaired hypoxic pulmonary vasoconstriction that might contribute to abnormal gas exchange and could be related to endothelial dysfunction in pulmonary arteries. The aim of the study was to investigate the response of PA to hypoxic stimulus in vitro in COPD, and the role of endothelium-derived nitric oxide (NO) in this response. Th...

X-linked congenital nephrogenic diabetes insipidus (cNDI) results from inactivating mutations of the human arginine vasopressin (AVP) V2 receptor (hV(2)R). Most of these mutations lead to intracellular retention of the hV(2)R, preventing its interaction with AVP and thereby limiting water reabsorption and concentration of urine. Because the majority of cNDI-hV(2)Rs exhibit protein misfolding, m...

This study aims to assess the repeatability and reproducibility of strain elastography in the evaluation of splenic nodules and to verify if it can differentiate benign from malignant splenic lesions in dogs. Twenty-four dogs with a single splenic hypoechoic lesion, underwent strain elastosonography. The strain ratio (SR) and hardness value (HV) were calculated. Repeatability and reproducibilit...

Background: Abnormality of hepatic vein (HV) waveform evaluated by Doppler ultrasonography has been widely studied in patients with chronic liver disease. The paper investigates the relationship between HV waveform changes, portal vein velocity (PVVel), hepatic artery pulsatility index (HAPI) and portal pressure (PP) measured directly from patients with portal hypertension (PHT), aiming to disc...

Four metabolism and two finishing trials were conducted to determine the effects of imposed feed intake variation on acidosis and performance of finishing steers. In Metabolism Trial 1, four ruminally fistulated steers were limit-fed and subjected to either a constant amount of feed per day (C) or low intake variation of .7 kg/d (LV). No treatment differences were found for intake or measures o...

This study aimed at identifying the performance of Family Health Strategy (FHS) nurses in home care. It consists of an exploratory descriptive study using a qualitative approach. Six FHS nurses from a health district of Porto Alegre, Rio Grande do Sul, Brazil, were interviewed. Data were submitted to thematic content analysis, revealing three categories: home visit (HV) in the FHS, assessment o...