Community case management (CCM) is a strategy for training and supporting workers at the community level to provide treatment for the three major childhood diseases--diarrhea, fever (indicative of malaria), and pneumonia--as a complement to facility-based care. Many low- and middle-income countries are now implementing CCM and need to evaluate whether adoption of the strategy is associated with...

Circadian clocks are critical modulators of metabolism. However, mechanistic links between cell autonomous clocks and metabolic processes remain largely unknown. Here, we report that expression of the biotin transporter slc5a6 gene is decreased in hearts of two distinct genetic mouse models of cardiomyocyte-specific circadian clock disruption [i.e., cardiomyocyte-specific CLOCK mutant (CCM) and...

Chronic illness affects approximately 50% of adults in the United States (Centers for Disease Control and Prevention, 2011). Nurses must be educationally prepared to meet the challenges of chronic disease management. The Chronic Care Model (CCM) is an effective framework for delivering planned, patient-centered care, with improved outcomes for individuals with chronic disease (Nutting et al., 2...

BACKGROUND AND PURPOSE Hyperpermeability and iron deposition are 2 central pathophysiological phenomena in human cerebral cavernous malformation (CCM) disease. Here, we used 2 novel MRI techniques to establish a relationship between these phenomena. METHODS Subjects with CCM disease (4 sporadic and 17 familial) underwent MRI imaging using the dynamic contrast-enhanced quantitative perfusion a...

Component-based software development allows developers to compose applications using software parts, called components. This approach represents an important step towards reducing development cost and time, and allows the creation of automated tools for software development. However, current applications have quality of service (QoS) requirements, and the existing component-based technologies p...

During growth of Pseudomonas in nutritionally rich environment many catabolicoperons are repressed by physiological control mechanisms. In the current reportwe have studied mechanisms that down-regulate transcription from the CatR-controlled promoter of phenol degradation genes pheBA in P. putida whenbacteria are growing in the presence of amino acids. We found that the amount o...

Le carcinome à cellules de Merkel (CCM) est une tumeur neuroendocrine très rare, de localisation cutanée primitive et d'évolution très grave. Sur le plan clinique, il s'agit d'un nodule inflammatoire dermo-hypodermique dur, bien circonscrit, dont la taille moyenne est de 1 à 3 cm, localisé sur les membres ou le visage. Des études récentes ont permis d'isoler un nouveau virus étroitement associé...

Introduction: The oral anticoagulant therapy (OAT), used to prevent thrombosis, is associated with substantial avoidable hospitalization. Aim: Identify the associations between chronic care management and the quality of OAT as suggested by the chronic care model (CCM) of Wagner. Methods: Regression analysis with data of 61 thrombosis clinics and inductive analysis with 63 interviews with health...

Study Design: the authors report on a clear cell meningioma (CCM) of the sacrum revealed 17 years after a removal of a spinal lesion. A review of 29 spinal CCM previously reported was done. Objective: To focus on clinical and biological behaviour of CCM. Summary of Background Data: CCM is a rare subtype characterrized by its inordinately aggressive clinical course despite its benign appearance....

FPGA-based Configurable Computing Machines (CCMs) offer powerful and flexible general-purpose computing platforms. However, development for FPGA-based designs using modern CAD tools is geared mainly toward an ASIC-like process. This is inadequate for the needs of CCM application development. This paper discusses an application framework for developing CCM-based applications beyond just the hard...