The human interleukin-5 receptor (hIL-5R) consists of a unique a subunit (hIL-5Ra) and a common b subunit (bc) that activate two Janus kinases (JAK1 and JAK2) and a signal transducer and activator of transcription (STAT5). The precise stoichiometry of the hIL-5R subunits and the role of JAK kinases used in IL-5 signaling were investigated. We analyzed the interaction between hIL-5Ra and bc by i...

A series of alpha,omega-bis donor substituted oligophenylenevinylene dimers held together by the [2.2]paracyclophane core were synthesized to probe how the number of repeat units and through-space delocalization influence two-photon absorption cross sections. Specifically, the paracyclophane molecules are tetra(4,7,12,15)-(4'-dihexylaminostyryl)[2.2]paracyclophane (3R(D)), tetra(4,7,12,15)-(4' ...

Full (1)H and (13)C NMR chemical shift assignments were made for two sets of penam beta-lactams: namely, the diastereomeric (2S, 5S, 6S)-, (2S, 5R, 6R)-, (2S, 5S, 6R)-, and (2S, 5R, 6S)-methyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylates (1-4) and (2S, 5R, 6R)-, (2S, 5S, 6R)-, and (2S, 5R, 6S)-6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4...

We have proposed previously that hemopoietic myeloid progenitors contribute to the ongoing recruitment of proinflammatory cells, namely eosinophils, to sites of allergen challenge in allergic diseases such as asthma. In this study, we investigated the involvement of bone marrow–derived progenitors in the development of allergen-induced pulmonary inflammation in mild asthmatic subjects. By flow ...

The objectives of the current study were to determine the amounts of aboveand below-ground plant biomass production, P uptake by forage, and P concentration of cool-season grass forage as influenced by management and season. Five forage management treatments were evaluated over 3 years in smooth bromegrass (Bromus inermis Leyss) pastures. Management practices were: ungrazed (U), hay harvest/fal...

The fine specificity of virus recognition by influenza A/PR8/34(H1N1)-specific cytolytic T lymphocyte (CTL) clones was analyzed with the use of a panel of syngeneic target cells infected with five heterologous influenza A strain viruses. Forty-five H-2 D-end-restricted CTL clones from B10.A(5R) responders (Dd,Ld) demonstrated 14 different patterns of recognition. Many of these clonotypes were a...

A method is described for the determination by solid phase spectrophotometry (SPS) of trace amounts of vanadium in natural water and crude petroleum samples. The procedure is based on fixation on a dextran-type anion exchanger of the complex V(IV)-Eriochrome Cyanine R. The absorbance of the gel, at 563 and 750 nm, packed in a 1 mm cell, is measured directly. Vanadium can be determined in the 0....

A Se-containing heptamethine cyanine dye based fluorescent probe was successfully developed and used for HClO detection with rapid response and high selectivity based on aggregation behavior. The probe could react with HClO with significant change in its fluorescence profile, which makes it practical for detecting HClO in fetal bovine serum and in living mice.