نتایج جستجو برای: رتروترنسپوزونهای ltr

تعداد نتایج: 3405  

Journal: :Journal of virology 1995
Y Su W Popik P M Pitha

We have examined the feasibility of using interferon (IFN) gene transfer as a novel approach to anti-human immunodeficiency virus type 1 (HIV-1) therapy in this study. To limit expression of a transduced HIV-1 long terminal repeat (LTR)-IFNA2 (the new approved nomenclature for IFN genes is used throughout this article) hybrid gene to the HIV-1-infected cells, HIV-1 LTR was modified. Deletion of...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
J Yang H S Malik T H Eickbush

The non-long terminal repeat (LTR) retrotransposon, R2, encodes a sequence-specific endonuclease responsible for its insertion at a unique site in the 28S rRNA genes of arthropods. Although most non-LTR retrotransposons encode an apurinic-like endonuclease upstream of a common reverse transcriptase domain, R2 and many other site-specific non-LTR elements do not (CRE1 and 2, SLACS, CZAR, Dong, R...

Journal: :Journal of molecular biology 2009
James C Stroud Amy Oltman Aidong Han Darren L Bates Lin Chen

The activation and latency of human immunodeficiency virus type 1 (HIV-1) are tightly controlled by the transcriptional activity of its long terminal repeat (LTR) region. The LTR is regulated by viral proteins as well as host factors, including the nuclear factor kappaB (NF-kappaB) that becomes activated in virus-infected cells. The two tandem NF-kappaB sites of the LTR are among the most highl...

2004
H. S. Malik Harmit S. Malik

ABC Fax + 41 61 306 12 34 E-mail [email protected] www.karger.com © 2005 S. Karger AG, Basel 1424–8581/05/1104–0392$22.00/0 Accessible online at: www.karger.com/cgr Abstract. Eukaryotic and prokaryotic genomes encode either Type I or Type II Ribonuclease H (RNH) which is important for processing RNA primers that prime DNA replication in almost all organisms. This review highlights the important ...

Journal: :Journal of virology 1997
S M Curristin K J Bird R J Tubbs A Ruddell

The avian leukosis virus (ALV) long terminal repeat (LTR) contains a compact transcription enhancer that is active in many cell types. A major feature of the enhancer is multiple CCAAT/enhancer element motifs that could be important for the strong transcriptional activity of this unit. The contributions of the three CCAAT/enhancer elements to LTR function were examined in B cells, as this cell ...

2013
Fiorella C. Grandi Wenfeng An

The human genome is laden with both non-LTR (long-terminal repeat) retrotransposons and microsatellite repeats. Both types of sequences are able to, either actively or passively, mutagenize the genomes of human individuals and are therefore poised to dynamically alter the human genomic landscape across generations. Non-LTR retrotransposons, such as L1 and Alu, are a major source of new microsat...

2015
Gabriele Capannini Domenico Dato Claudio Lucchese Monica Mori Franco Maria Nardini Salvatore Orlando Raffaele Perego Nicola Tonellotto

Ranking is a central task of many Information Retrieval (IR) problems, particularly challenging in the case of large-scale Web collections where it involves effectiveness requirements and efficiency constraints that are not common to other ranking-based applications. This paper describes QuickRank, a C++ suite of efficient and effective Learning to Rank (LtR) algorithms that allows high-quality...

Journal: :Nucleic acids research 1992
R Toyama S M Bende R Dhar

We have analyzed the transcriptional activity of the human immunodeficiency virus type I (HIV-1) LTR promoter in the fission yeast Schizosaccharomyces pombe (S.pombe). The ability of a series of 5'-deleted forms of the HIV-1 LTR promoter to direct transcription of the chloramphenicol acetyltransferase reporter gene was studied. We found that the HIV-1 promoter is functional in S.pombe and that ...

آیدا اسماعیل زاده سیلابی, سیدحسن تقوایی مرجان نعمتی‌مهر کورش گلکار,

توسعه شهری به‌عنوان بخش جدیدی از اکوسیستم طبیعی موجود، کارکرد اکولوژیک و خدمات اکوسیستمی آن را دگرگون می‌سازد. تأثیرات منفی این تغییرات باید تا حد امکان تقلیل و تجربه محیط طبیعی توسط مردم تداوم یابد. افزایش تجربه طبیعت، سلامت روانی و جسمانی افراد را متأثر ساخته، به‌...

Journal: :Journal of virology 1983
A Itin E Keshet

VL30 DNA represents a retrovirus-like multigene family of mice whose genetic origin is unknown. We have now determined the primary nucleotide sequences and the adjacent sequences of the long terminal direct repeats (LTRs) possessed by a randomly selected VL30 unit. The LTR of the VL30 unit comprised 435 nucleotide base pairs and had an inverted repeat of five bases at its 5' and 3' termini. At ...

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