The purpose of this study was to develop a compaction technique to enhance the solubility, dissolution rate and other physicochemical properties of poorly water-soluble drug indomethacin (IM) with different polymers. The IM was compacted with the different polymers like hydroxy propyl methylcellulose (HPMC), Kollicoat IR, Chitosan, Polyvinyl Pyrrolidone without using any binder and solvent. Pol...

In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K(30) with different enriched samples of evodiamine to PVP K(30) ratios were prepared by solvent method. Our studies showed that the dissolution rate of evodiamine was significantly higher in the solid dispersion system in comparison with that in enriched samples of evodiamine or physical mixtu...

Alone and combined effects of cyclodextrins (βCD and HPβCD), surfactant (Tween-80) and PVP on the solubility and dissolution rate of etoricoxib were evaluated in a series of 2 factorial design. The complexes of etoricoxib – CDs (βCD and HPβCD) were prepared with and without Tween-80 and PVP by kneading method as per 2 factorial designs. The solubility of etoricoxib in eight selected fluids cont...

Large quantities of methane hydrate are present in marine sediment. When methane hydrate is exposed or released to seawater, it dissolves in seawater or dissociates into methane gas and water. There was some confusion in the literature about the kinetics of these processes. It is critical to realize that dissolution and dissociation are two different processes. Dissolution is due to instability...

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotatin...

In order to simulate the in vivo dissolution of drugs, biorelevant dissolution media (BDM), simulating the gastric or intestinal juices are often employed. For gastric BDM, pH, surface tension and osmolality is simulated, however, viscosity has, to our knowledge not been taken into account. The dissolution rate of a drug compound is influenced by the viscosity of the dissolution medium. In the ...

OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...

A physical model which assumes that hydroxyapatite is the thermodynamic governing phase for the acid dissolution-rate behavior of enamel has been critically examined theoretically and experimentally. Both enamel powder and synthetic hydroxyapatite initial dissolution-rate experiments were conducted under various conditions of acid-butler type and concentration, pH, and common ion concentrations.

INTRODUCTION The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. METHODS Solid dispersion formulations with different carriers including crospovidone, microcrystalline cellulose, Elaeagnus angustifolia fruit powder, with different drug to carrier ratios were prepared employing cogrinding method. Dissolution st...