The patient effective dose, E, is an indicator of the stochastic radiation risk associated with radiographic or fluoroscopic x-ray examinations. Determining effective doses for radiologic examinations by measurement or calculation is generally very difficult. By contrast, the energy imparted, epsilon, to the patient may be obtained from the x-ray exposure-area product incident on the patient. A...

Stable isotope fractionation was studied during the degradation of m-xylene, o-xylene, m-cresol, and p-cresol with two pure cultures of sulfate-reducing bacteria. Degradation of all four compounds is initiated by a fumarate addition reaction by a glycyl radical enzyme, analogous to the well-studied benzylsuccinate synthase reaction in toluene degradation. The extent of stable carbon isotope fra...

Tyrosine phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) within CD3 chains is crucial for the recruitment of protein tyrosine kinases and effector molecules into the T cell receptor. Thus, phenylalanine substitution at the N-terminal tyrosine residue of the CD3-epsilon-ITAM abolished signal transduction functions of this ITAM, including phosphorylation at the C-termin...

The polymerase subunit (alpha) of Escherichia coli DNA polymerase III holoenzyme and the 3'----5' exonuclease subunit (epsilon) are each less active separately than together in the holoenzyme core (an assembly of alpha, epsilon, and theta subunits). In a complex formed from purified alpha and epsilon subunits, polymerase activity increased 2-fold, and that of the 3'----5' exonuclease increased ...

An embedding $\varphi \colon (M_1, \omega_1) \to (M_2, \omega_2)$ (of symplectic manifolds of the same dimension) is called $\epsilon$-symplectic if difference $\varphi^* \omega_2 - \omega_1$ $\epsilon$-small with respect to a fixed Riemannian metric on $M_1$. We prove that sequence embeddings converges uniformly (on compact subsets) another embedding, then limit $E$-symplectic, where number $E...

Exonucleolytic editing is a major contributor to the fidelity of DNA replication by the multisubunit DNA polymerase (pol) III holoenzyme. To investigate the source of editing specificity, we have studied the isolated exonuclease subunit, epsilon, and the pol III core subassembly, which carries the epsilon, theta, and alpha (polymerase) subunits. Using oligonucleotides with specific terminal mis...

We investigate practical selection of hyper-parameters for support vector machines (SVM) regression (that is, epsilon-insensitive zone and regularization parameter C). The proposed methodology advocates analytic parameter selection directly from the training data, rather than re-sampling approaches commonly used in SVM applications. In particular, we describe a new analytical prescription for s...

Fast inhibitory synaptic transmission in the brain relies on ionotropic GABA(A) receptors (GABA(A)R). Eighteen genes code for GABA(A)R subunits, but little is known about the epsilon subunit. Our aim was to identify the synaptic transmission properties displayed by native receptors incorporating epsilon. Immunogold localization detected epsilon at synaptic sites on locus coeruleus (LC) neurons....

BACKGROUND AND PURPOSE Diazoxide, a well-known opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has been demonstrated to exert cardioprotective effect against ischemic injury through the mitoK(ATP) channel and protein kinase C (PKC). We aimed to clarify the role of PKC isoforms and the relationship between the PKC isoforms and the mitoK(ATP) channel in diazoxide-induced...