نتایج جستجو برای: جهش itd
تعداد نتایج: 4993 فیلتر نتایج به سال:
Effectively targeting leukemia-initiating cells (LIC) in FLT3-ITD-mutated acute myeloid leukemia (AML) is crucial for cure. Tyrosine kinase inhibitors (TKI) have limited impact as single agents, failing to eradicate LIC in the bone marrow. Using primary AML samples and a patient-derived xenograft model, we investigated whether combining the FLT3-selective TKI crenolanib with the hypomethylating...
Bilateral cochlear implantation is becoming more common as clinicians attempt to provide better sound-source localization and speech reception in noise for cochlear implant (CI) users. While some improvement over the abilities of monolateral implantees has been documented, bilateral performance for CI users is far from that achieved with normal hearing. Identifying factors that limit bilateral ...
BACKGROUND Fms-like tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutation is related to poor prognosis in normal-karyotype acute myeloid leukemia (AML). However, the prognostic significance of the mutation at relapse has not been adequately investigated. We investigated the prognostic significance of the FLT3 ITD mutation at relapse in normal-karyotype AML patients. METHODS We ana...
Neurons in the medial superior olive (MSO) are thought to encode interaural time differences (ITDs), the main binaural cues used for localizing low-frequency sounds in the horizontal plane. The underlying mechanism is supposed to rely on a coincidence of excitatory inputs from the two ears that are phase-locked to either the stimulus frequency or the stimulus envelope. Extracellular recordings ...
The auditory steady-state evoked response (ASSR) is a scalp-recorded potential elicited by modulated sounds or repetitive transient sounds presented at a high rate. The binaural interaction component (BIC) of the ASSR equals the difference between the response to binaural stimuli and the sum of the responses to a monaural stimulus presented to the left ear and the right ear. This study examined...
Acute myeloid leukemia with normal karyotype (NK-AML) represents a cytogenetic grouping with intermediate prognosis but substantial molecular and clinical heterogeneity. Within this subgroup, presence of FLT3 (FMS-like tyrosine kinase 3) internal tandem duplication (ITD) mutation predicts less favorable outcome. The goal of our study was to discover gene-expression patterns correlated with FLT3...
Activating mutations in FLT3 (Fms-like tyrosine kinase 3) by internal tandem duplication (ITD) mutations are found in approximately 30% of patients with acute myeloid leukemia (AML) and are associated with poor outcome in this patient population. Numerous FLT3 inhibitors have been tested for the treatment of AML, but these inhibitors have shown variable responses that were attributed to heterog...
Binaural recordings of noise in rooms were used to determine the relationship between binaural coherence and the effectiveness of the interaural time difference (ITD) as a cue for human sound localization. Experiments showed a strong, monotonic relationship between the coherence and a listener's ability to discriminate values of ITD. The relationship was found to be independent of other, widely...
In this study we searched the obtainable accuracy of forest inventory based on the individual tree detection (ITD) by using fusion of automatic ITD (ITDauto) and visual interpretation of laser point clouds. Current ITD algorithms, mostly based on segmentation of canopy height models (CHMs), are not able to utilize the whole information included in three-dimensional point clouds. We hypothesized...
Localization of sound sources relies on 2 main binaural cues: interaural time differences (ITD) and interaural level differences. ITD computing is first carried out in tonotopically organized areas of the brainstem nucleus laminaris (NL) in birds and the medial superior olive (MSO) in mammals. The specific way in which ITD are derived was long assumed to conform to a delay line model in which a...
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