N-n-butyl haloperidol iodide (F2), a novel compound, has shown palliative effects in myocardial ischemia/reperfusion (I/R) injury. In this study, we investigated the effects of F2 on the extracellular signal-regulated kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)/Na(+)/H(+) exchanger (NHE)/Na(+)/Ca(2+) exchanger (NCX) signal-transduction pathway involved in H2O2-induced Ca(2+)...

Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitochondrial viral pathogenicity factor. A full-length PB1-F2 has been present in all human influenza p...

OBJECTIVE Maternal undernutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. We investigated whether these effects may persist in subsequent generations. DESIGN Historical cohort study. SETTING Interview during a clinic or home visit or by telephone. POPULATION Men and women born in the Wilhelmina Gasthuis in Amsterdam between Nove...

Integrins are cell surface receptors crucial for cell migration and adhesion. They are activated by interactions of the talin head domain with the membrane surface and the integrin β cytoplasmic tail. Here, we use coarse-grained molecular dynamic simulations and nuclear magnetic resonance spectroscopy to elucidate the membrane-binding surfaces of the talin head (F2-F3) domain. In particular, we...

Carter & Local [3] report acoustic data showing that in two varieties of British English, the liquids /l/ and /r/ are polarised in terms of ‘darkness’ along the F2 dimension; Leeds English has dark onset /l/ (low F2) and a light onset /r/ (high F2), and Newcastle English has the opposite pattern. Here we report data on liquid polarisation for Australian English, a variety reported to show a ver...

rH..il:ribllltlton.-tr'ee two-sample test is proposed tha t is an extension of the Wilcoxon test with arbitrary censoring on the right. The test is conditional on the pattern ~ha.t~TV:&l>ll~l..lll. The null hypothesis is H0 : F1(t) = F2(t) (t ~ T) agai nst either H1 : F1(t) < F 2(t) (t ~ T) or H2 : F1(t) < F2(t) or F1(t) > F2 (t) (t ~ T), '~here .l\,F2 are cumulative distributions (discrete or ...

A large body of evidence indicates that measurement of F2-isoprostanes, specific prostaglandin F2-like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F2-isoprostanes in the early 1990s, a variety of analytical approaches has been introduced for the quantification of these novel compou...

Circulating interferon production, induced by Newcastle disease virus, is about seven times higher in C57 Black mice than in Balb/c/Gif mice. A Mendelian analysis was carried out and circulating interferon production was measured in reciprocal F1 hybrids, in the F2 generation, in progeny of backcrosses of F1 hybrids to either parent strain, and in second backcross progeny. The results indicate ...

The duration of blood feeding by similar-sized Aedes aegypti (L.) was determined under laboratory conditions in Trinidad, West Indies. Ae. aegypti from the F0 generation contained individuals that fed quickly (106.2 seconds) as well as slowly (330.0 seconds). Among the fast feeders (<2 min), the time taken for blood feeding during the first gonotrophic cycle was much shorter than that observed ...