نتایج جستجو برای: جزیره ی بیماری زای cag
تعداد نتایج: 147101 فیلتر نتایج به سال:
In Huntington's disease (HD), the size of the expanded HTT CAG repeat mutation is the primary driver of the processes that determine age at onset of motor symptoms. However, correlation of cellular biochemical parameters also extends across the normal repeat range, supporting the view that the CAG repeat represents a functional polymorphism with dominant effects determined by the longer allele....
The eVect of CAT trinucleotide interruptions in the CAG trinucleotide repeats of the SCA1 gene on the age at onset of spinocerebellar ataxia type 1 (SCA1) was investigated. The number of CAG repeats in SCA1 was determined by polymerase chain reaction (PCR) analysis, and the presence of CAT interruptions was assessed on the basis of the sensitivity of the PCR products to the restriction endonucl...
A population from the Wuchereria bancrofti-endemic island of Mauke was reevaluated retrospectively by use of the Og4C3 circulating antigen (CAg) enzyme-linked immunosorbent assay to assess active infection in relation to host responses by age and gender. Use of microfilaremia (Mf) alone misclassified approximately 50% of infected people, although CAg and Mf levels were positively correlated. Le...
مقدمه: امروزه، بهترین مدل ارزیابی و درمان درد مزمن عضلانی- اسکلتی، مدل ترس- اجتناب است که نقش عوامل آسیب زای درد (روان رنجوری، اجتناب تجربی و عواطف منفی) در آن به خوبی مشخص نشده است. هدف از انجام مطالعه ی حاضر، بررسی الگوی ساختاری روابط بین عوامل آسیب زای درد، فاجعه آفرینی، ترس از درد و سازگاری با درد (شدت و ناتوانی درد) در چارچوب مدل ترس- اجتناب بود. روش ها: 314 بیمار مبتلا به دردهای مزمن عضلا...
The severity of symptoms elicited by the widespread human pathogen Helicobacter pylori is strongly influenced by the genetic diversity of the infecting strain. Among the most important pathogen factors that carry an increased risk for gastric cancer are specific genotypes of the cag pathogenicity island (cag-PAI), encoding a type IV secretion system (T4SS) responsible for the translocation of t...
Background: Trinucleotide repeats CAG (n) in androgen receptor gene is thought to be central to PCOS genetic susceptibility. However, previous studies of PCOS have shown variable association of CAG (n) polymorphism with PCOS. Objective: To assess the association of the AR gene CAG repeat length polymorphism with PCOS among Egyption patients, and its influence on clinical and biochemical androge...
Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological exami...
OBJECTIVE We aimed to evaluate the role of gated myocardial perfusion SPECT (MPS) and to investigate whether only the invasive coronary angiography (CAG) is sufficient in the diagnosis of the coronary artery disease (CAD) in women. MATERIAL AND METHODS Sixty-four women (62±10 years) with known CAD were included in this study. They had echocardiography (ECHO), stress/rest gated MPS and invasiv...
AIM Previous studies have reported a 10.2%-22% rate of silent cerebral infarction and a 0.1%-1% rate of symptomatic cerebral infarction after coronary angiography (CAG). However, the risk factors of cerebral infarction after CAG have not been fully elucidated. For this reason, we investigated the incidence and risk factors of CVD complications within 48 h after CAG using magnetic resonance imag...
Expansion of CAG repeats, which code for the disease-causing polyglutamine protein, is a common feature in polyglutamine diseases. RNA-mediated mechanisms that contribute to neuropathology in polyglutamine diseases are important. RNA-toxicity describes a phenomenon by which the mutant CAG repeat RNA recruits RNA-binding proteins, thereby leading to aberrant function. For example the MID1 protei...
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