Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the retina in a rat ...

BACKGROUND The gut microbiota is associated with the modulation of mucosal immunity and the etiology of inflammatory bowel diseases (IBD). Previous studies focused on the impact of bacterial species on IBD but seldom suspected archaea, which can be a major constituent of intestinal microbiota, to be implicated in the diseases. Recent evidence supports that two main archaeal species found in the...

The generalized linear moving sampling scheme (MSS) exploiting the second-order statistics and also high-order cumulants is studied, where set of MSS defined as shifted distance offsets involved in estimation based on a platform. Then, sparse physical arrays (SPAs) with nonuniform schemes (NL-MSS), referred to SPA-NL-MSS, are proposed optimize consecutive difference co-arrays. For same number s...

Differences in the pathogenesis of microsatellite stable (MSS) sporadic colorectal cancers (CRCs) between left-sided CRC (LC) and right-sided CRC (RC) have not been clarified. To identify pathogenesis-related genomic differences between MSS CRCs within the two locations, we performed a comprehensive molecular analysis using crypt isolation with samples from 92 sporadic CRCs. Microsatellite inst...

The lack of consistence and convergence is often considered as a major drawback of smoothed particle hydrodynamics (SPH). Here, we analysis two errors introduced by typical conservative SPH approximations of the gradient of a scalar field: one (smoothing error) is due to smoothing of the gradient by an integration associated with a kernel function; the other (integration error) is due to approx...

Management support systems (MSS) help managers to perform their jobs more efficiently. With in-memory technology, a new IT enabler promises to support managers by benefits ranging from reducing time for MSS data entry and analysis to completing even new topics of analysis. Hence, the present situation is favorable for an MSS redesign applying in-memory apps. Such apps are fieldtested and ready-...

PURPOSE A medical school's mission statement (MS) is an expression of its vision and a reflection of the broader social environment in which it is embedded. The authors examine how the institutional identity of U.S. medical education is projected through the MSs of all U.S. MD-granting medical schools. In addition, the authors examine the extent to which differences between subsets of schools (...

صخلملا Seasonal variation of zooplankton biomass has been carried out at two selected sites on Greater Zab River. Monthly samples of water were collected during period from January to December 2008. Some physico-chemical properties of water were studied including water temperature (from 8 to 30.5 C), hydrogen ion concentration (from 6.3 to 8), EC (from 255 to 821 μs.cm), turbidity (1085 NTU), d...

Microsatellites (MSs) are DNA regions consisting of repeated short motif(s). MSs are linked to several diseases and have important biomedical applications. Thus, researchers have developed several computational tools to detect MSs. However, the currently available tools require adjusting many parameters, or depend on a list of motifs or on a library of known MSs. Therefore, two laboratories ana...

AIM To investigate the cytotoxicity of a modified salt solution (MSS) and evaluate the antimicrobial properties of MSS on in vitro biofilm models. METHODOLOGY In a metabolic assay, fibroblasts derived from periodontal ligaments (PDL) of human extracted teeth were cultured and challenged with MSS or controls. Then, in active attachment biofilm models, the efficacy of MSS in the presence of den...