BACKGROUND People with Parkinson's disease (PD) have an increased risk of developing dementia (PDD), which often has clinical features similar to dementia with Lewy bodies (DLB). Whilst perfusion studies have shown parieto-occipital hypoperfusion in DLB and PDD relative to controls, there have not been any longitudinal studies of perfusion changes in PDD and DLB. METHODS In this study, we mea...

The purpose of this study was to evaluate whether bile acid malabsorption assessed by the 75SeHCAT test, had a pathogenetic role in functional chronic diarrhoea and to ascertain whether the small bowel transit time (SBTT) could be correlated with the 75SeHCAT test results. The test was based on the counting of the abdominal retention of a 75-selenium labelled homotaurocholic acid. The 75SeHCAT ...

Purpose: To develop a floating multiparticulate unit system for metoprolol tartarate, using a porous carrier, with an outcome for delayed gastric emptying. Methods: Dried microparticles of metoprolol tartarate were prepared by solvent evaporation using Eudragit ® RS-PO, polypropylene foam powder, and dichloromethane as release-rate modifying polymer, floating aid and solvent respectively. The s...

OBJECTIVES To investigate the correlation between anosognosia and behavioural symptoms, performance on executive tests, and frontal cortex regional cerebral blood flow (rCBF) in patients with 'amnestic mild cognitive impairment' (MCI) and mild Alzheimer's disease (AD). METHODS From a prospective Memory Clinic cohort including consecutively referred patients, age 60 years or above, and with MM...

introduction acute lymphoblastic leukemia (all) is the most common malignancy of childhood. patients with all commonly present with easy bruising and infections due to medullary involvement. the extra medullary involvements of all manifests as hepatosplenomegaly, lymphadenopathy, and testicular enlargement. among extramedullary manifestations of the all, thyroid involvement is rare. herein, we ...

Background Congenital hypothyroidism (CH) may cause alterations in the child's global development. The current study aimed to screen the global development of children with and without congenital hypothyroidism, focusing on communication, and cognitive abilities and to ...

We read with interest the article by Gafton et al published in 2012. The authors illustrated the use of a dual-phase CT protocol for the enhancement characterization of parathyroid lesions and suggested the elimination of precontrast and delayed scan phases from 4D CT to reduce radiation exposure. In this letter, we describe the alternative approach of our institution to 4D CT. Our modified 4D ...