This study aimed to investigate the effects of polymorphisms of the flavin-containing mono-oxygenase 3 (FMO3) and flavin-containing mono-oxygenase 6 (FMO6) genes on the pharmacokinetics of sulindac sulfide, the active metabolite of sulindac, in patients with preterm labor. Ten single-nucleotide polymorphisms (SNPs) were genotyped, and plasma sulindac sulfide concentrations were measured at 0, 1...

Richey, Joyce M., Marilyn Ader, Donna Moore, and Richard N. Bergman. Angiotensin II induces insulin resistance independent of changes in interstitial insulin. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E920–E926, 1999.—We set out to examine whether angiotensin-driven hypertension can alter insulin action and whether these changes are reflected as changes in interstitial insulin (the signal to...

Radziuk, Jerry, and W.-N. Paul Lee. Measurement of gluconeogenesis and mass isotopomer analysis based on [U-13C]glucose. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E199–E207, 1999.—Two methods of measuring rates of gluconeogenesis based on label redistribution after the introduction of [U-13C]glucose into the whole body are examined. These methods are compared with methods previously derived ...

Roberts, Christian K., R. James Barnard, Arnie Jasman, and Thomas W. Balon. Acute exercise increases nitric oxide synthase activity in skeletal muscle. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E390–E394, 1999.—This study examined the effects of acute exercise on skeletal muscle nitric oxide synthase (NOS) activity. Female Sprague-Dawley rats were divided into three groups: control, exercise...

Quaroni, Andrea, Jean Q. Tian, Michael Göke, and Daniel K. Podolsky. Glucocorticoids have pleiotropic effects on small intestinal crypt cells. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1027–G1040, 1999.—Glucocorticoids have long been known to accelerate maturation of the intestinal tract, but the molecular mechanisms that account for their physiological function in the epithelium ...

Wu, Sing-Yung, Daniel H. Polk, Wen-Sheng Huang, and Delbert A. Fisher. Fetal-to-maternal transfer of 3,38,5triiodothyronine sulfate and its metabolite in sheep. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E915–E919, 1999.— Earlier studies have shown that sulfoconjugation is a major pathway of thyroid hormone metabolism in fetal mammals. To assess the placental transfer of sulfoconjugates in th...

Wick, Debra A., Bellur Seetharam, and Nancy M. Dahms. Biosynthesis and secretion of the mannose 6-phosphate receptor and its ligands in polarized Caco-2 cells. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G506–G514, 1999.—We have analyzed the transport of newly synthesized mannose 6-phosphate (Man-6-P)-bearing proteins (i.e., lysosomal enzymes) in the polarized human colon adenocarcin...

I'm sorry to say that there's hardly a word that is research based in this " 40 years hard labour " , but what surprises me is that my observation and experience is sometimes supported by subsequent research. This is an anecdotal account which I hope you will enjoy and find peppered with controversy, pearls of wisdom, and food for thought, but I expect it will not add one jot to the body of you...

Ming, Zhi, Chao Han, and W. Wayne Lautt. Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1200–G1206, 1999.—The involvement of nitric oxide (NO) in the vascular escape from norepinephrine (NE)-induced vasoconstriction was investigated in the hepatic arterial vasculature of anesthetized cats. ...