Diffusion is not the main process by which drugs are disposed throughout the body. Translational movements of solutes given by different energy-consuming mechanisms are required in order to dispose them efficiently. Membrane transportation and cardiac output distribution are two effective processes to move the molecules among different body sites. Gastrointestinal-blood cycling constitutes a su...

Chronic hepatitis C is the leading cause of advanced liver disease in the Western world. Most patients with liver cirrhosis develop portal hypertension (PHT) (i.e. an abnormal gradient between portal and inferior vena cava pressures), responsible for the most frequent and severe complications of liver disease and, as a consequence, the main cause of death and liver transplantation in those pati...

A, Nickeleit V et al. C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques. Cardiopulmonary assessment of patients with end-stage kidney disease Sir, The recent investigation by Agarwal highlights the need to consider pulmonary disease as part of the cardiovascu-lar disease spectrum among end-stage renal disease (ESRD) patients. The prevalence of pul...

Pulmonary hypertension (PHT) commonly co-exists with significant mitral regurgitation (MR), but its prevalence and prognostic importance have not been well documented.

We report the case of a recurrent phosphaturic mesenchymal tumor (PHT) of the right acetabulum in a 47-year-old man with a long history of hip pain. After primary excision of the PHT, successful remission was expected due to normal phosphate levels. Over a long period, a recurrence led to destruction of the acetabulum and loosening of the back plate of the hip prosthesis. One-year follow-up aft...

Gingival overgrowths are lesions which can be seen due to diffe rent reasons. Phenytoin (PHT), the drug used in the treatment of epilepsy, is probably one of the commonest causes of gingival overgrowth. In the presented case, a male patient aged 23, who has been taking PHT for the treatment of epilepsy, subsequently manifested by the enlarged gingival tissue, which was cut out using gingivectom...

Two sorts of poly(3-hexylthiophene) (PHT) films with the same chemical compositions were prepared, and their electrochemical, spectroscopic, and transport properties were studied with a special interest in a possible influence of film structure on mobilities of charge carriers. One of the PHT films was electrochemically synthesized using 3-hexylthiophene as a monomer (as-grown film) and the oth...

To evaluate the ef®cacy and safety of phenytoin (PHT) in the treatment of situation-related seizures and epilepsies in the newborn and infant; the clinical histories of 82 patients were retrospectively reviewed. Sixty patients received for status epilepticus (SE), intravenous PHT followed by long-term oral administration for 27 of them. The other 22 patients had oral treatment only. Intravenous...

A new hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase (PHT) was detected in two variant lines of Nicotiana tabacum L. (TX1, TX4) accumulating markedly different levels of caffeoylputrescine. The enzyme accepted only the aliphatic diamines putrescine, cadaverine and 1,3-diaminopropane at a ratio of 100:33:8. Caffeoyl- and feruloyl-CoAs were the best acyl donors. The apparent K(m)-val...