Nontyphoidal Salmonella species cause gastrointestinal disease worldwide. The prevailing theory of Salmonella enteropathogenesis is that bacterial invasion of the intestinal epithelium is essential for virulence and that this requires the virulence-associated genomic region Salmonella pathogenicity island 1 (SPI-1). Recent studies of Salmonella enterica infection models have demonstrated that e...

Software process improvement (SPI) has been around for decades: frameworks are proposed, success factors are studied, and experiences have been reported.However, the sheermass of concepts, approaches, and standards published over the years overwhelms practitioners as well as researchers. What is out there? Are there new trends and emerging approaches?What are open issues? Still, we struggle to ...

The Standardized Precipitation Index (SPI) is now widely used throughout the world in both a research and an operational mode. For arid climates, or those with a distinct dry season where zero values are common, the SPI at short time scales is lower bounded, referring to non-normally distributed in this study. In these cases, the SPI is always greater than a certain value and fails to indicate ...

Realistic representation of vegetation’s response to drought is important for understanding terrestrial carbon cycling. We evaluated nine Earth system models from the historical experiment of the Coupled Model Intercomparison Project Phase 5 for the response of gross primary productivity (GPP) and leaf area index (LAI) to hydrological anomalies. Hydrological anomalies were characterized by the ...

We have previously reported the cloning of the Salmonella enterica serovar Typhimurium SPI-1 secretion system and the use of this clone to functionally complement a ΔSPI-1 strain for type III secretion activity. In the current study, we discovered that S. Typhimurium cultures containing cloned SPI-1 display an adherent biofilm and cell clumps in the media. This phenotype was associated with hyp...

Invasive salmonellosis caused by Salmonella enterica involves an enteric stage of infection where the bacteria colonize mucosal epithelial cells, followed by systemic infection with intracellular replication in immune cells. The type III secretion system encoded in Salmonella Pathogenicity Island (SPI)-2 is essential for intracellular replication and the regulators governing high-level expressi...

Human plasmacytoid dendritic cells (pDCs), also called type 2 dendritic cell precursors or natural interferon (IFN)-producing cells, represent a cell type with distinctive phenotypic and functional features. They are present in the thymus and probably share a common precursor with T and natural killer (NK) cells. In an effort to identify genes that control pDC development we searched for genes ...

OBJECTIVE To explore the validity, reliability, and applicability of using a short, psychometrically sound survey instrument to measure population attitudes toward tobacco control policies. DESIGN Surveys. SUBJECTS AND SETTING Student respondents attending university in Australia (n = 403), Hong Kong (n = 336), the Netherlands (n = 351), South Africa (n = 291), the United Kingdom (n = 164) ...

One of the most popular ways to improve the software development capability in organizations is to embark upon a Software Process Improvement (SPI) program based on one of the existing capability maturity models. Some of the challenges in norm-based SPI are to create commitment to the norm in the organization, to involve all parts of the organization in the SPI program, and to create opportunit...