We studied the pharmacokinetics of dichloroacetate (DCA) in naive rats and rats depleted of glutathione S-transferase-zeta (GST-zeta), at doses approaching human daily exposure levels. We also compared in vitro metabolism of DCA by rat and human liver cytosol. Jugular vein-cannulated male Fischer-344 rats received graded doses of DCA ranging from 0.05 to 20 mg/kg (intravenously or by gavage), a...

The adhesion of three fschericbia co/i strains on to six poly(methacrylates) differing in hydrophohicity and surface charge was measured as a function of time under laminar flow conditions. Polymers used were poly(methyl methacrylate) (PMMA), poly( hydroxyethyl methacrylate) (PHEMA) and copolymers of MMA or HEMA with either 15% methacrylic acid (MAA) or 15% trimethylaminoethyl methacrylate-HCI ...

We introduce and study elliptic zeta values, a two-parameter deformation of the values of Riemann’s zeta function at positive integers. They are essentially Taylor coefficients of the logarithm of the elliptic gamma function, and share the SL(3,Z) modular properties of this function. Elliptic zeta values at even integers are related to Eisenstein series and thus to sums of odd powers of divisor...

Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspase-independent apoptotic pathway, is responsible for photoreceptor death. In this work, we investigated the activation of a pro-survival k...

Let X be a complete, geometrically irreducible, singular, algebraic curve defined over a field of characteristic p big enough. Given a local ring OP,X at a rational singular point P of X, we attached a universal zeta function which is a rational function and admits a functional equation if OP,X is Gorenstein. This universal zeta function specializes to other known zeta functions and Poincaré se...

The aim of this paper is to establish some properties solutions the Dirichlet–Neumann problem: $$(\partial _z\partial _{\overline{z}})^2 w=g$$ in unit disc $${{\mathbb {D}}}$$ , $$w=\gamma _0$$ and $$\partial _{\nu }\partial _{\overline{z}}w=\gamma $$ on $${\mathbb {T}}$$ (the circle), $$\frac{1}{2\pi i}\int _{{\mathbb {T}}}w_{\zeta {\overline{\zeta }}}(\zeta )\frac{d\zeta }{\zeta }=c$$ where _...

We compute the equivariant zeta function for bundles over infinite graphs and for infinite covers. In particular, we give a “transfer formula” for the zeta function of infinite graph covers. Also, when the infinite cover is given as a limit of finite covers, we give a formula for the limit of the zeta functions.

As analogue to special values at positive integers of the Riemann zeta function, we consider Carlitz zeta values ζC(n) at positive integers n. By constructing t-motives after Papanikolas, we prove that the only algebraic relations among these characteristic p zeta values are those coming from the Euler-Carlitz relations and the Frobenius p-th power relations.