نتایج جستجو برای: تست mpn
تعداد نتایج: 18267 فیلتر نتایج به سال:
This study was conducted to detect the presence of rope-producing Bacillus spp. and the rope spore counts in one hundred samples of different types of bread obtained from several bakeries and supermarket stores in Bursa province and to identify the isolates at the species level. Rope spore counts determined using the Most Probable Number (MPN) technique varied between 30 and 90 MPN/g in eight s...
and ample material for future investigations. Jerez et al focused on the SH2 domain in their search for mutations. 1 However, some of the gain-of-function STAT3 mutations found in hepatocellular carcinoma are outside this domain, 4 suggesting that all domains of the STAT3 gene should also be closely inspected before we call them truly wild-type. Detailed sequence analysis could also solve the c...
In this issue of Blood, Yan et al and Walz et al exploit mouse genetics to investigate the contribution of signal transducer and activator of transcription 5 (STAT5) to the abnormal in vivo growth of hematopoietic cells expressing JAK2(V617F) or BCR-ABL. Eliminating STAT5 expression had dramatic effects in both contexts, and this new work and other recent studies support the therapeutic potenti...
BACKGROUND The discovery of Janus kinase 2 (JAK2)-V617F has provided important insight into the pathogenesis of Philadelphia-negative chronic myeloproliferative neoplasms (Ph-negative MPNs); however, the etiology of JAK2(V617F)-negative Ph-negative MPN remains unidentified. MPL(W515L) and MPL(W515K) (MPL(W515L/K)) are 2 gain-of-function mutations, which have been found in some Ph-negative MPN p...
Fluoride pollution in waters has engulfed worldwide regions and an excess of fluoride intake always causes skeletal fluorosis. Herein, a novel hybrid nanomaterial ZrP-MPN was fabricated for fluoride retention by encapsulating nano-ZrP onto macroporous polystyrene materials modified with quaternary ammonium groups. The as-obtained materials exhibited favorable removal of fluoride ions from aqueo...
We previously found that gender influenced the JAK2 V617F allele burden, but it is unknown whether this gender difference in molecular epidemiology influences complications in the myeloproliferative neoplasms (MPNs). Historically, vascular complications represented the most common cause of mortality in polycythemia vera and essential thrombocytosis and contributed to morbidity in primary myelof...
A rapid and precise assay for neuraminidase using 2-(3'-methoxyphenyl)-N-acetyl-alpha-neuraminic acid (MPN) is described. It is proposed that this substrate be used for the standardization of activity of neuraminidases from viral, bacterial, and mammalian sources. MPN is also used as a chromogenic substrate to localize influenza and parainfluenza virus foci in tissue culture. This technique per...
The JAK2(V617F) mutation does not elucidate the phenotypic variability observed in myeloproliferative neoplasm (MPN) families. A putative tumor suppressor gene, TET2, was recently implicated in MPN and myelodysplastic syndromes through the identification of acquired mutations affecting hematopoietic stem cells. The present study analyzed the TET2 gene in 61 MPN cases from 42 families. Fifteen d...
..........................................................................................1 CHAPTER I: INTRODUCTION....................................................................3 CHAPTER II: Steroidal Regulation of synaptic density in the magnocellular division of the medial preoptic nucleus (MPN mag) of the Syrian Hamster..............................19 Introduction.........................
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