In bacteria, many genes involved in the biosynthesis of cofactors such as thiamine pyrophosphate (TPP) are regulated by ribo switches, regions in the 5' end of mRNAs to which the cofactor binds, thereby affecting translation and/or transcription. TPP riboswitches have now been identified in fungi, in which they alter mRNA splicing. Here, we show that addition of thiamine to cultures of the mode...

Experimental observation of Tamm plasmon-polariton (TPP) and surface plasmonpolariton (SPP) hybrid mode in metal/photonic crystal system is reported. Interaction between TPP and SPP leads to repulsion of their dispersion curves.

Benzene, toluene, p-xylene, and [60]fullerene are shown to be weak ligands to a hard metal such as iron(III) in Fe(TPP)+ cation (TPP ) tetraphenylporphyrinate). X-ray crystal structures of [Fe(TPP)(C6H6)][CB11H6Br6]‚3.5C6H6 (1), [Fe(TPP)(C7H8)][CB11H6Cl6]‚2C7H8 (2), [Fe(TPP)(C8H10)][Ag(CB11H6Br6)2]‚ arene (3), and [Fe(TPP)(C60)][F20-BPh4]‚2.5dichlorobenzene (4) show distinctively short Fe‚‚‚C c...

Objective. Thyrotoxic periodic paralysis (TPP), a known condition in Asian men, is becoming increasingly common in men from Western countries. Since suspicion for TPP as a differential in diagnosis is of utmost importance to avoid overcorrection of hypokalemia and other complications, we are reporting a case of TPP in a 25-year-old Caucasian male. Methods. The patient presented with intermitten...

In 1,2-difluorobenzene (DFB), electrolyte conductivity measurements and cyclic voltammetric titration on the traditional benchmark tetraphenylporphyrin, H(2)tpp, permit the first estimate of ion pair association constants for singly- and doubly-oxidized free-base porphyrins. From ion titration cyclic voltammetry and digital simulation, measured association constants for H(2)tpp(+)X(-) were 65, ...

Reduced graphene oxide (RGO)-porphyrin (TPP) nanohybrids (RGO-TPP 1 and RGO-TPP 2) were prepared by two synthetic routes that involve functionalization of the RGO using diazonium salts. The microscopic structures, morphology, photophysical properties and nonlinear optical performance of the resultant RGO-TPP nanohybrids were investigated. The covalent bonding of the porphyrin-functionalized-RGO...

Therapeutic advances have markedly prolonged overall survival in multiple myeloma (MM) but the disease currently remains incurable. In a panel of MM cell lines (MM.1S, OPM-2, H929, and U266), using CD138 immunophenotyping, side population staining, and stem cell-related gene expression, we demonstrate the presence of stem-like tumor cells. Hypoxic culture conditions further increased CD138low s...

Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis. Factors like high-carbohydrate meal exercise, steroid, and stress can precipi...

The most widespread riboswitch class, found in organisms from all three domains of life, is responsive to the vitamin B(1) derivative thiamin pyrophosphate (TPP). We have established that a TPP-sensing riboswitch is present in the 3' untranslated region (UTR) of the thiamin biosynthetic gene THIC of all plant species examined. The THIC TPP riboswitch controls the formation of transcripts with a...

Fluorescent probes are one of the most popularly used bioimaging markers to monitor metabolic processes of living cells. However, long-term light excitation always leads to photobleaching of fluorescent probes, unavoidable autofluorescence as well as photodamage of cells. To overcome these limitations, we synthesized a type of photostable luminogen named TPE-TPP with an aggregation induced emis...