Hematopoietic myeloproliferative neoplasms (MPNS) with rearrangements of the receptor tyrosine kinase FGFR1 gene, located on chromosome 8p11, are uncommon and associated with diverse presentations such as atypical chronic myeloid leukemia, acute myeloid leukemia, or an acute T- or B-lymphoblastic leukemia, reflecting the hematopoietic stem cell origin of the disease. A review of MPN patients wi...

There has been a long history of reports describing a variety of paraneoplastic phenomena associated with myelodysplastic syndromes, particularly those with autoimmune manifestations. We report here a series of patients with an antecedent myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) that underwent aggressive transformation to acute myeloid leukemia (AML). In each case, th...

The prognostic heterogeneity of the World Health Organization category of "systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease" (SM-AHNMD) has not been systematically validated by primary data. Among 138 consecutive cases with SM-AHNMD, 123 (89%) had associated myeloid neoplasm: 55 (45%) myeloproliferative neoplasm (SM-MPN), 36 (29%) chronic myelomonocytic leuk...

Abnormal hematopoietic stem/progenitor cell (HSPC) signaling is a hallmark of leukemic hematopoiesis and a common denominator in the pathobiology of all types of myeloid malignancies. The most studied pathways are the JAK/ STAT, MAPK/ERK and PI3K/AKT cascades [1]. Constitutive activation of STAT molecules has been reported in almost all myeloid malignancies. Basal STAT3 and less often STAT5 lev...

Chronic inflammation is suggested to contribute to the Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) disease initiation and progression, as well as the development of premature atherosclerosis and may drive the development of other cancers in MPNs, both nonhematologic and hematologic. The MPN population has a substantial comorbidity burden, including cerebral, cardiovascula...

The aims of this study were to evaluate two methods, qPCR and a chemiluminescent assay (ColiLight II), for rapid detection of E. coli in water, and to examine the survival and persistence of clinical E. coli in drinking water and biofilm using qPCR and ColiLight II. qPCR and ColiLight II were compared with a cultivation-based method (MPN), and survival and persistence of four clinical E. coli s...

This study was conducted to detect the presence of rope-producing Bacillus spp. and the rope spore counts in one hundred samples of different types of bread obtained from several bakeries and supermarket stores in Bursa province and to identify the isolates at the species level. Rope spore counts determined using the Most Probable Number (MPN) technique varied between 30 and 90 MPN/g in eight s...

and ample material for future investigations. Jerez et al focused on the SH2 domain in their search for mutations. 1 However, some of the gain-of-function STAT3 mutations found in hepatocellular carcinoma are outside this domain, 4 suggesting that all domains of the STAT3 gene should also be closely inspected before we call them truly wild-type. Detailed sequence analysis could also solve the c...

In this issue of Blood, Yan et al and Walz et al exploit mouse genetics to investigate the contribution of signal transducer and activator of transcription 5 (STAT5) to the abnormal in vivo growth of hematopoietic cells expressing JAK2(V617F) or BCR-ABL. Eliminating STAT5 expression had dramatic effects in both contexts, and this new work and other recent studies support the therapeutic potenti...