Variable sensitivity to T-cell-receptor (TCR)- and IL-7-receptor (IL-7R)-mediated homeostatic signals among naïve T cells has thus far been largely attributed to differences in TCR specificity. We show here that even when withdrawn from self-peptide-induced TCR stimulation, CD8(+) T cells exhibit heterogeneous responses to interleukin-7 (IL-7) that are mechanistically associated with IL-7R expr...

Reading a book is also kind of better solution when you have no enough money or time to get your own adventure. This is one of the reasons we show the developments in telecommunications with a focus on ss7 network reliability as your friend in spending the time. For more representative collections, this book not only offers it's strategically book resource. It can be a good friend, really good ...

For high-accuracy template-based-modeling of CASP7 targets, we have applied a procedure based on the rigorous optimization of score functions at three stages: multiple alignment, chain building, and side-chain modeling. We applied the conformational space annealing method to a newly developed consistency based score function for multiple alignment. For chain building, we optimized the MODELLER ...

In this paper we give an overview of challenges and chances of the integration of methylation data into Electronic Health Records. Perspectives of methylation data in terms of clinical relevance and characteristics of these data are shown. Among several standards OpenEHR, HL7 CG and LOINC are identified as starting point for the representation and communication of methylation data within the cl...

A method for adult content classification and nudity detection is presented. Objective of this method is to classify images into different classes, varying on the degree of adult content. We utilize MPEG-7 descriptors to represent visual information. Skin regions are detected to model adult content more precisely, as well as to eliminate false-positives. Proposed method is tested with conventio...

Recently, a number of methods have been proposed to improve image retrieval accuracy by capturing context information. These methods try to compensate for the fact that a visually less similar image might be more relevant because it depicts the same object. We propose a new quick method for refining any pairwise distance metric, it works by iteratively discovering the object in the image from t...

Total syntheses of (+)-7-epi-goniofufurone, (+)-goniopypyrone and (+)-goniofufurone have been achieved from an advanced common precursor formed from D-(+)-mannitol by changing the carbinol protection profile.

The analysis of video recorded surgical procedures is considered to be a useful extension of the medical curriculum. We can foster the development of video-based e-learning courses by working out a unified description method which would facilitate the exchange of these materials between different platforms. Sophisticated metadata enables a broader integration of artificial intelligence techniqu...